Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2022 Sep 17;23(18):10899.
doi: 10.3390/ijms231810899.

The Influence of Graphene Content on the Antibacterial Properties of Polycaprolactone

Maciej B Hajduga  1 , Rafał Bobinski  1 , Mieczysław Dutka  1 , Jan Bujok  1 , Michał Cwiertnia  1 , Celina Pajak  1 , Anna Kurowska  2 , Izabella Rajzer  2
Affiliations

The Influence of Graphene Content on the Antibacterial Properties of Polycaprolactone

Maciej B Hajduga et al. Int J Mol Sci. .

Abstract

This work contains an analysis of the impact of modifying a bioresorbable polymer-polycaprolactone (PCL)-with various additives on its antibacterial properties. To this end, samples of PCL filament containing various content levels of graphene (GNP), 0.5%, 5%, 10%, were obtained using injection molding. Polymer samples without additives were used for comparison. The next step was to assess the antimicrobial impact of the preparations under study against the following microorganisms: Staphylococcus aureus ATCC 25293, Escherichia coli ATCC 25922, Candida albicans ATCC 10231. Effective bactericidal activity of PCL with small amount of GNP, especially against C. albicans and S. aureus was confirmed. A decrease in this property or even multiplication of microorganisms was observed in direct proportion to the graphene content in the samples.

Keywords: antibacterial; biomaterials; graphene; polycaprolactone.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
SEM (Scanning Electron Microscope) images of GNP additives.
Figure 2
Figure 2
The macroscopic images of obtained composite sticks.
Figure 3
Figure 3
Microscopic images of obtained filaments and its cross section: PCL/GNP_0.5 (a,b); PCL/GNP_5 (c,d); PCL/GNP_10 (e,f). Red arrows indicates graphene concentration.
Figure 4
Figure 4
SEM images of PCL_GNP_0.5 stick surface at different magnifications (a–d).
Figure 5
Figure 5
Cultivation of C. albicans.
Figure 6
Figure 6
Average ABE values for S. aureus.
Figure 7
Figure 7
Average ABE values for C. albicans.
Figure 8
Figure 8
Shape of PCL with 10% GNP samples for microbiological tests.
See this image and copyright information in PMC

References

    1. Yang Y., Yan H., Kang X., Zhibin Z. Advances in Application Research of Polycaprolactone. New Chem. Mater. 2011;39:13–15.
    1. Lo H.Y., Kuo H.T., Huang Y.Y. Application of Polycaprolactone as an Anti-Adhesion Biomaterial Film. Artif. Org. 2010;34:648–653. doi: 10.1111/j.1525-1594.2009.00949.x. - DOI - PubMed
    1. Lam C.X., Savalani M.M., Teoh S.H., Hutmacher D.W. Dynamics of in vitro polymer degradation of polycaprolactone-based scaffolds: Accelerated versus simulated physiological conditions. Biomed. Mater. 2008;3:034108. doi: 10.1088/1748-6041/3/3/034108. - DOI - PubMed
    1. Chen D.R., Bei J.Z., Wang S.G. Polycaprolactone microparticles and their biodegradation. Polym. Degrad. Stabil. 2000;67:455–459. doi: 10.1016/S0141-3910(99)00145-7. - DOI
    1. Cho H.S., Moon H.S., Kim M., Nam K., Kim J.Y. Biodegradability and biodegradation rate of poly(caprolactone)—Starch blend and poly(butylene succinate) biodegradable polymer under aerobic and anaerobic environment. Waste Manag. 2011;31:475–480. doi: 10.1016/j.wasman.2010.10.029. - DOI - PubMed

LinkOut - more resources