Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2022 Sep 7;11(18):5277.
doi: 10.3390/jcm11185277.

Massive Thrombosis of Mitral Bioprosthesis Due to SARS-CoV-2 Infection

Mariateresa Librera  1 , Stefania Paolillo  1   2 , Guido Carlomagno  1 , Gianluca Santise  1 , Antonio Mariniello  1 , Saverio Nardella  1 , Carlo Briguori  1 , Daniele Maselli  1
Affiliations
Case Reports

Massive Thrombosis of Mitral Bioprosthesis Due to SARS-CoV-2 Infection

Mariateresa Librera et al. J Clin Med. .

Abstract

Thromboembolic events have been reported as frequent and fearsome complications in patients affected by SARS-CoV-2 infection. Patients undergoing cardiac valve replacement exhibit an increased risk of valve thrombosis, even with prosthetic biological valves, and especially in the first period after surgery. The management of these patients is challenging and requires prompt interventions. We report the case of a young woman infected by SARS-CoV-2 three months after double cardiac valve replacement that developed a massive prosthetic biological valve thrombosis despite optimal anticoagulant therapy.

Keywords: COVID-19; SARS-CoV-2; heart valve prosthesis; thrombosis.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Timeline graph of events and INR levels. ER: emergency room.
Figure 2
Figure 2
Cardiac CT showing extensive thrombotic stratifications in the left atrium, both on the posterior free wall (yellow arrows) as well as in the peri-annular region near the prosthesis ring (red arrows).
Figure 3
Figure 3
Transesophageal echocardiography showing massive thrombosis of mitral prosthetic leaflets, prevalently on the ventricular side, a stratified thrombus on the left atrial free wall (A–C,F), increased gradients on the mitral prosthesis (D), and reduced orifice area at 3D en-face view (E).
See this image and copyright information in PMC

References

    1. Bikdeli B., Madhavan M.V., Jimenez D., Chuich T., Dreyfus I., Driggin E., Nigoghossian C., Ageno W., Madjid M., Guo Y., et al. COVID-19 and Thrombotic or Thromboembolic Disease: Implications for Prevention, Antithrombotic Therapy, and Follow-Up: JACC State-of-the-Art Review. J. Am. Coll. Cardiol. 2020;75:2950–2973. doi: 10.1016/j.jacc.2020.04.031. - DOI - PMC - PubMed
    1. Alexander S.A., Fergus I.V., Lerakis S. Bioprosthetic Valve Thrombosis Associated with COVID-19 Infection. Circ. Cardiovasc. Imaging. 2021;14:e012118. doi: 10.1161/CIRCIMAGING.120.012118. - DOI - PubMed
    1. Khan H.M.W., Khan M.R., Munir A., Moughrabieh A., Changezi H.U. A Giant Right-Heart Thrombus-in-Transit in a Patient with COVID-19 Pneumonia. Am. J. Case Rep. 2020;21:e927380. doi: 10.12659/AJCR.927380. - DOI - PMC - PubMed
    1. Llopis Gisbert G., Vidal Urrutia V., Moruno Benita M.A., Payá Chaume A., Berenguer Jofresa A., Cubillos Arango A.M., Pérez Boscá J.L., Payá Serrano R. Bioprosthetic Valve Thrombosis and Obstruction Secondary to COVID-19. Can. J. Cardiol. 2021;37:938.e3–938.e6. doi: 10.1016/j.cjca.2020.10.008. - DOI - PMC - PubMed
    1. Vahanian A., Beyersdorf F., Praz F., Milojevic M., Baldus S., Bauersachs J., Capodanno D., Conradi L., De Bonis M., De Paulis R., et al. 2021 ESC/EACTS Guidelines for the management of valvular heart disease. Eur. Heart J. 2022;43:561–632. doi: 10.1093/eurheartj/ehab395. - DOI - PubMed

Publication types

LinkOut - more resources