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Review
. 2022 Sep 19;11(18):5487.
doi: 10.3390/jcm11185487.

Correlation between Oral Lichen Planus and Viral Infections Other Than HCV: A Systematic Review

Alberta Lucchese  1 , Dario Di Stasio  1 , Antonio Romano  1 , Fausto Fiori  1 , Guido Paolo De Felice  2 , Carlo Lajolo  3 , Rosario Serpico  1 , Francesco Cecchetti  4 , Massimo Petruzzi  5   6
Affiliations
Review

Correlation between Oral Lichen Planus and Viral Infections Other Than HCV: A Systematic Review

Alberta Lucchese et al. J Clin Med. .

Abstract

Objectives: This review aimed to evaluate the correlation between viral infections (HPV, EBV, HSV-1, CMV) other than HCV and oral lichen planus to assess if there is sufficient evidence to establish if these viruses can play a role in the etiopathogenesis of the disease.

Materials and methods: We reviewed the literature using different search engines (PubMed, ISI Web of Science, and the Cochrane Library), employing MeSH terms such as "oral lichen planus" and "OLP" in conjunction with other terms. We utilized the Population, Intervention, Comparison, Outcomes, and Study design (PICOS) method to define our study eligibility criteria.

Results: A total of 43 articles of the 1219 results initially screened were included in the study. We allocated the 43 selected items into four groups, according to each related virus: HPV, EBV, HSV-1, and CMV.

Conclusions: Heterogeneous results neither confirm nor exclude a direct correlation between the investigated viral infections and oral lichen planus etiopathogenesis and its feasible malignant transformation. Many viral agents can cause oral lesions and act as cancerizing agents. Future studies could be desirable to produce comparable statistical analyses and enhance the quantity and quality of the outcomes to promote the translation of research into clinical practice.

Keywords: CMV; EBV; HPV; HSV-1; oral cancer; oral lichen planus.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
The flowchart explicates the steps made during the selection process.
See this image and copyright information in PMC

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