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. 2022 Sep 13;12(9):1424.
doi: 10.3390/life12091424.

Renessans Helps in Early Clearance of SARS-CoV-2: In-Vivo Activity of the Iodine Complex in Rhesus macaque

Muhammad Nawaz  1 , Muhammad Adnan Ashraf  1 , Muhammad Asad Ali  1 , Muhammad Zubair Shabbir  1 , Muhammad Abu Bakr Shabbir  1 , Imran Altaf  1 , Sohail Raza  1 , Saira Rafique  1 , Sohail Hassan  1 , Nageen Sardar  1 , Adnan Mehmood  1 , Muhammad Waqar Aziz  1 , Sehar Fazal  1 , Muhammad Tahir Khan  1 , Hafiz Muhammad Moavia Atique  1 , Ali Asif  1 , Zia Ullah  2 , Mubashir Iqbal  1 , Talha Imtiaz  1 , Muhammad Anwar  1 , Nadia Mukhtar  1 , Tahir Yaqub  1
Affiliations

Renessans Helps in Early Clearance of SARS-CoV-2: In-Vivo Activity of the Iodine Complex in Rhesus macaque

Muhammad Nawaz et al. Life (Basel). .

Abstract

Iodine complexes have known antimicrobial properties along with reported in-vitro antiviral activity for several viruses. Renessans is one such product with iodine complexes and ascorbic acid. The present study was designed to determine its efficacy for SARS-CoV-2 in Rhesus macaque. Rhesus macaque were assigned to: A) prophylactic group (n = 3), (B) treatment group (n = 3), (C) infection control group (n = 4), and (D) negative control group (n = 4). Groups A, B, and C were challenged with 2 × 106 TCID of SARS-CoV-2. The prophylactic group (A) was administered Renessans from 5 days before infection till 8 days postinfection (DPI). The treatment group (B) was administered Renessans from 3 till 8 DPI. Group C was administered water-insoluble fractions only. Nasal swabs from all monkeys of groups A, B, and C remained positive for SARS-CoV-2 till 2 and 7 DPI, while the swabs became negative for groups A and B at 14 DPI. Likewise, fecal matter of monkeys in group A returned negative results during the experiment, while that of group B had significantly decreased viral load (101.5 genome copies/mL) compared to group C (103 genome copies/mL). Hence, it is concluded that Renessans has in-vivo SARS-CoV-2 activity and may result in early clearance of SARS-CoV-2.

Keywords: COVID-19; animal trial; antiviral; coronavirus; iodine compound.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Detailed timeline of events for determining the in-vivo efficacy of the antiviral drug (Renessans) for SARS-CoV-2.
Figure 2
Figure 2
Longitudinal comparison of average fecal viral load of experimental and control groups.
Figure 3
Figure 3
Graphical representation of the comparison of average nasal viral load of experimental and control groups. ***: p < 0.01, ns: non-significant.
See this image and copyright information in PMC

References

    1. Lake M.A. What We Know so Far: COVID-19 Current Clinical Knowledge and Research. Clin. Med. 2020;20:124. doi: 10.7861/clinmed.2019-coron. - DOI - PMC - PubMed
    1. WHO Statement on the Second Meeting of the International Health Regulations (2005) Emergency Committee Regarding the Outbreak of Novel Coronavirus (2019-NCoV) [(accessed on 18 August 2020)]. Available online: https://www.who.int/news-room/detail/30-01-2020-statement-on-the-second-...
    1. Worldometer Coronavirus Cases. [(accessed on 18 July 2020)]. Available online: https://www.worldometers.info/coronavirus/
    1. Wang X., Cao R., Zhang H., Liu J., Xu M., Hu H., Li Y., Zhao L., Li W., Sun X., et al. The Anti-Influenza Virus Drug, Arbidol Is an Efficient Inhibitor of SARS-CoV-2 in Vitro. Cell Discov. 2020;6:4–8. doi: 10.1038/s41421-020-0169-8. - DOI - PMC - PubMed
    1. Zheng Y.-Y., Ma Y.-T., Zhang J.-Y., Xie X. COVID-19 and the Cardiovascular System. Nat. Rev. Cardiol. 2020;17:259–260. doi: 10.1038/s41569-020-0360-5. - DOI - PMC - PubMed

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