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. 2022 Sep 6;27(18):5753.
doi: 10.3390/molecules27185753.

Two Novel Sesquiterpenoid Glycosides from the Rhizomes of Atractylodes lancea

Lanying Liu  1 , Fuqin Guan  2 , Yu Chen  2 , Fan Wang  2   3 , Pengxu Chen  2   3 , Min Yin  2 , Bi Wang  2 , Linwei Li  2 , Qizhi Wang  2 , Yonghua Gu  2 , Xu Feng  2   3
Affiliations

Two Novel Sesquiterpenoid Glycosides from the Rhizomes of Atractylodes lancea

Lanying Liu et al. Molecules. .

Abstract

Secoatractylohexone A (1), an unprecedented secoguaiane lactone glycoside featuring 6/7 cores and dihydroxy-9-guaine-3-one 11-O-β-d-glucopyranoside (2), a 9,10-unsaturated guaiene-type glycoside possessing an uncommon scaffold, were isolated from the water-soluble portion of the ethanolic extract of Atractylodes lancea rhizomes together with five known compounds (3-7). The structures of 1 and 2 were elucidated on the basis of extensive spectroscopic data and application of the CD technique. The potential biological activities of secoatractylohexone A were predicted by network pharmacology in silico, the result of which indicated that secoatractylohexone A may be used to treat type II diabetes.

Keywords: Atractylodes lancea; network pharmacology; secoatractylohexone A; sesquiterpenoid glycosides.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
The chemical structures of compounds 1–7.
Figure 2
Figure 2
The key 2D NMR correlations and the ECD spectra of compound 1 (A,B) and compound 2 (C,D).
Figure 3
Figure 3
The network pharmacology analysis of secoatractylohexone A. (A) GO analysis of the candidate targets. Database shows the ten hub enriched items in the biological processes (BP), cell component (CC), and molecular function (MF). (B) The KEGG pathways of the candidate targets. (C) Related indications of the candidate targets. (D) The protein–protein interaction networks of the candidate targets.
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