. 2022 Sep 16;14(18):3836.

doi: 10.3390/nu14183836.

Comparison of the Coincidence of Osteoporosis, Fracture, Arthritis Histories, and DEXA T-Score between Monozygotic and Dizygotic Twins: A Cross-Sectional Study Using KoGES HTS Data

Hyo Geun Choi¹, So Young Kim², Bong Cheol Kwon³, Ho Suk Kang⁴, Hyun Lim⁴, Joo-Hee Kim⁵, Ji Hee Kim⁶, Seong Jin Cho⁷, Eun Sook Nam⁷, Kyueng Whan Min⁸, Ha Young Park⁹, Nan Young Kim¹⁰, Younghee Choi^{11

12}, Mi Jung Kwon¹³

Affiliations

¹ Department of Otorhinolaryngology-Head & Neck Surgery, Hallym University Sacred Heart Hospital, College of Medicine, Hallym University, Anyang 14068, Korea.
² Department of Otorhinolaryngology-Head & Neck Surgery, CHA Bundang Medical Center, College of Medicine, CHA University, Seongnam 13488, Korea.
³ Department of Orthopedic Surgery, Hallym University Sacred Heart Hospital, College of Medicine, Hallym University, Anyang 14068, Korea.
⁴ Division of Gastroenterology, Department of Internal Medicine, Hallym University Sacred Heart Hospital, College of Medicine, Hallym University, Anyang 14068, Korea.
⁵ Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, Hallym University Sacred Heart Hospital, College of Medicine, Hallym University, Anyang 14068, Korea.
⁶ Department of Neurosurgery, Hallym University Sacred Heart Hospital, College of Medicine, Hallym University, Anyang 14068, Korea.
⁷ Department of Pathology, Kangdong Sacred Heart Hospital, College of Medicine, Hallym University, Seoul 05355, Korea.
⁸ Department of Pathology, Hanyang University Guri Hospital, College of Medicine, Hanyang University, Guri 11923, Korea.
⁹ Department of Pathology, Busan Paik Hospital, College of Medicine, Inje University, Busan 47392, Korea.
¹⁰ Hallym Institute of Translational Genomics and Bioinformatics, Medical Center, Hallym University, Anyang 14068, Korea.
¹¹ Department of Pathology, Hallym University Dongtan Sacred Heart Hospital, College of Medicine, Hallym University, Hwaseong 18450, Korea.
¹² Research Institute for Complementary & Alternative Medicine, Hallym University, Anyang 14068, Korea.
¹³ Department of Pathology, Hallym University Sacred Heart Hospital, College of Medicine, Hallym University, Anyang 14068, Korea.

PMID: 36145209
PMCID: PMC9506177
DOI: 10.3390/nu14183836

Comparison of the Coincidence of Osteoporosis, Fracture, Arthritis Histories, and DEXA T-Score between Monozygotic and Dizygotic Twins: A Cross-Sectional Study Using KoGES HTS Data

Hyo Geun Choi et al. Nutrients. 2022.

. 2022 Sep 16;14(18):3836.

doi: 10.3390/nu14183836.

Authors

Affiliations

¹ Department of Otorhinolaryngology-Head & Neck Surgery, Hallym University Sacred Heart Hospital, College of Medicine, Hallym University, Anyang 14068, Korea.
² Department of Otorhinolaryngology-Head & Neck Surgery, CHA Bundang Medical Center, College of Medicine, CHA University, Seongnam 13488, Korea.
³ Department of Orthopedic Surgery, Hallym University Sacred Heart Hospital, College of Medicine, Hallym University, Anyang 14068, Korea.
⁴ Division of Gastroenterology, Department of Internal Medicine, Hallym University Sacred Heart Hospital, College of Medicine, Hallym University, Anyang 14068, Korea.
⁵ Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, Hallym University Sacred Heart Hospital, College of Medicine, Hallym University, Anyang 14068, Korea.
⁶ Department of Neurosurgery, Hallym University Sacred Heart Hospital, College of Medicine, Hallym University, Anyang 14068, Korea.
⁷ Department of Pathology, Kangdong Sacred Heart Hospital, College of Medicine, Hallym University, Seoul 05355, Korea.
⁸ Department of Pathology, Hanyang University Guri Hospital, College of Medicine, Hanyang University, Guri 11923, Korea.
⁹ Department of Pathology, Busan Paik Hospital, College of Medicine, Inje University, Busan 47392, Korea.
¹⁰ Hallym Institute of Translational Genomics and Bioinformatics, Medical Center, Hallym University, Anyang 14068, Korea.
¹¹ Department of Pathology, Hallym University Dongtan Sacred Heart Hospital, College of Medicine, Hallym University, Hwaseong 18450, Korea.
¹² Research Institute for Complementary & Alternative Medicine, Hallym University, Anyang 14068, Korea.
¹³ Department of Pathology, Hallym University Sacred Heart Hospital, College of Medicine, Hallym University, Anyang 14068, Korea.

PMID: 36145209
PMCID: PMC9506177
DOI: 10.3390/nu14183836

Abstract

We explored the genetic and environmental inter-relationships among osteoporosis, fracture, arthritis, and bone mineral density concordance in monozygotic twins compared to those in dizygotic twins. This cross-sectional research assessed data of 1032 monozygotic and 242 dizygotic twin pairs aged >20 years included in the Healthy Twin Study data of the Korean Genome and Epidemiology Study between 2005 and 2014. Outcomes of interest included illness concordance and absolute differences in dual-energy X-ray absorptiometry (DEXA) T-scores. We found comparable concordances of osteoporosis, fractures, osteoarthritis, and rheumatoid arthritis between monozygotic and dizygotic twins. Medical histories of osteoporosis, fractures caused by accident or falling, osteoarthritis, and rheumatoid arthritis were not distinct between monozygotic and dizygotic twins. Accidental fracture occurrence in both monozygotic twins showed significantly lower odds than that in dizygotic twins. Genetic influence on liability to fracture risk might thus be maintained. DEXA T-scores for bone mineral density indicated more comparable tendencies within monozygotic twin pairs than within dizygotic ones, suggesting the relative importance of genetic contribution to bone mineral density. The relative importance of genetic factors in bone mineral density is sustained between monozygotic twins; overt disease expression of osteoporosis, fractures, or arthritis may be affected by environmental factors.

Keywords: aging; bone mineral density; dizygotic twins; environmental factors; fracture; genetic factors; monozygotic twins; osteoarthritis; osteoporosis; rheumatoid arthritis.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

**Figure 1**
The study design of the present study; 1032 monozygotic twins and 242 dizygotic twins were compared for concordance of several aging-related bone and joint diseases, including osteoporosis, fracture, osteoarthritis, and rheumatoid arthritis between twins. DEXA T-scores for bone mineral density were also compared.

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Comparison of the Coincidence of Osteoporosis, Fracture, Arthritis Histories, and DEXA T-Score between Monozygotic and Dizygotic Twins: A Cross-Sectional Study Using KoGES HTS Data

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Comparison of the Coincidence of Osteoporosis, Fracture, Arthritis Histories, and DEXA T-Score between Monozygotic and Dizygotic Twins: A Cross-Sectional Study Using KoGES HTS Data

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