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Review
. 2022 Sep 7;14(18):3725.
doi: 10.3390/polym14183725.

Electrospun Nanofiber Composites for Drug Delivery: A Review on Current Progresses

Renatha Jiffrin  1 , Saiful Izwan Abd Razak  1   2 , Mohamad Ikhwan Jamaludin  1 , Amir Syahir Amir Hamzah  3 , Muadz Ahmad Mazian  4 , Muhammad Azan Tamar Jaya  5 , Mohammed Z Nasrullah  6 , Mohammed Majrashi  7 , Abdulrahman Theyab  8   9 , Ahmed A Aldarmahi  10 , Zuhier Awan  11 , Mohamed M Abdel-Daim  12   13 , Abul Kalam Azad  14
Affiliations
Review

Electrospun Nanofiber Composites for Drug Delivery: A Review on Current Progresses

Renatha Jiffrin et al. Polymers (Basel). .

Abstract

A medication's approximate release profile should be sustained in order to generate the desired therapeutic effect. The drug's release site, duration, and rate must all be adjusted to the drug's therapeutic aim. However, when designing drug delivery systems, this may be a considerable hurdle. Electrospinning is a promising method of creating a nanofibrous membrane since it enables drugs to be placed in the nanofiber composite and released over time. Nanofiber composites designed through electrospinning for drug release purposes are commonly constructed of simple structures. This nanofiber composite produces matrices with nanoscale fiber structure, large surface area to volume ratio, and a high porosity with small pore size. The nanofiber composite's large surface area to volume ratio can aid with cell binding and multiplication, drug loading, and mass transfer processes. The nanofiber composite acts as a container for drugs that can be customized to a wide range of drug release kinetics. Drugs may be electrospun after being dissolved or dispersed in the polymer solution, or they can be physically or chemically bound to the nanofiber surface. The composition and internal structure of the nanofibers are crucial for medicine release patterns.

Keywords: drug delivery; drug release; electrospinning; nanofiber; nanofiber composite.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
The annual value of scientific publications correlated to electrospinning for the past 22 years. [Data analysis of articles was done using Scopus (The premier source for scientific, technological, and medical research worldwide)] as of 7 July 2022, using the keywords “Electrospinning nanofiber”.
Figure 2
Figure 2
The electrospinning process and schematic setup of the electrospinning.
Figure 3
Figure 3
The essential parameters for the electrospinning process.
Figure 4
Figure 4
An illustration of the filler material integrated with the base material producing a reinforced composite.
Figure 5
Figure 5
The important characteristics of the nanofiber composite.
Figure 6
Figure 6
An illustration of the coaxial electrospinning setup.
Figure 7
Figure 7
An illustration of quercetin/phenanthroline incorporated with polycaprolactone/gelatin.
Figure 8
Figure 8
A schematic diagram showing how the nanofibrous membrane helps to fight oral pathogens with composite properties.
Figure 9
Figure 9
A schematic diagram of how essential oil incorporated with polymer works on combating Escherichia coli and Staphylococcus aureus.
See this image and copyright information in PMC

References

    1. Ramos A.P., Cruz M.A.E., Tovani C.B., Ciancaglini P. Biomedical applications of nanotechnology. Biophys. Rev. 2017;9:79–89. doi: 10.1007/s12551-016-0246-2. - DOI - PMC - PubMed
    1. Sahay R., Kumar P.S., Sridhar R., Sundaramurthy J., Venugopal J., Mhaisalkar S.G., Ramakrishna S. Electrospun composite nanofibers and their multifaceted applications. J. Mater. Chem. 2012;22:12953–12971. doi: 10.1039/c2jm30966a. - DOI
    1. Azad A.K., Al-Mahmood S.M.A., Kennedy J.F., Chatterjee B., Bera H. Electro-hydrodynamic assisted synthesis of lecithin-stabilized peppermint oil-loaded alginate microbeads for intestinal drug delivery. Int. J Biol. Macromol. 2021;185:861–875. doi: 10.1016/j.ijbiomac.2021.07.019. - DOI - PubMed
    1. Licciardello M., Tonda-Turo C., Gallina A., Ciofani G., Ciardelli G. Fabrication of extracellular matrix-like membranes for loading piezoelectric nanoparticles. J Phys. Mater. 2020;3:034004. doi: 10.1088/2515-7639/ab8572. - DOI
    1. Kelleher C.M., Vacanti J.P. Engineering extracellular matrix through nanotechnology. J. R. Soc. Interface. 2010;7:S717–S729. doi: 10.1098/rsif.2010.0345.focus. - DOI - PMC - PubMed

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