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Review
. 2022 Sep 13;14(9):2022.
doi: 10.3390/v14092022.

Management of Chronic Hepatitis B in HIV-Coinfected Patients

Massimo Fasano  1 , Maria Cristina Poliseno  2 , Josè Ramon Fiore  2 , Sergio Lo Caputo  2 , Antonella D'Arminio Monforte  3 , Teresa Antonia Santantonio  2
Affiliations
Review

Management of Chronic Hepatitis B in HIV-Coinfected Patients

Massimo Fasano et al. Viruses. .

Abstract

Hepatitis B virus infection occurs in approximately 7% of people living with HIV (PLWH), with substantial regional variation and higher prevalence among intravenous drug users. Early studies on the natural history of HIV/HBV coinfection demonstrated that in coinfected patients, chronic hepatitis B (CHB) has a more rapid progression than in HBV-monoinfected patients, leading to end-stage liver disease complications, including hepatocellular carcinoma. Therefore, the adequate management of CHB is considered a priority in HIV-coinfected patients. Several guidelines have highlighted this issue and have provided recommendations for preventing and treating HBV infection. This article discusses the management of liver disease in patients with HIV/HBV coinfection and summarizes the current and future therapeutic options for treating chronic hepatitis B in this setting.

Keywords: chronic hepatitis B; coinfection HIV-HBV; hepatitis B; hepatitis B virus; hepatocellular carcinoma; human immunodeficiency virus; treatment.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Algorithm for the management of HBV infection in PLWH.
See this image and copyright information in PMC

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