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. 2022 Sep 6:16:931727.
doi: 10.3389/fnhum.2022.931727. eCollection 2022.

Cerebral hemodynamic changes to transcranial Doppler sonography in celiac disease: A pilot study

Francesco Fisicaro  1 , Giuseppe Lanza  2   3 , Carmela Cinzia D'Agate  4 , Manuela Pennisi  1 , Mariagiovanna Cantone  5   6 , Giovanni Pennisi  2 , Marios Hadjivassiliou  7 , Rita Bella  8
Affiliations

Cerebral hemodynamic changes to transcranial Doppler sonography in celiac disease: A pilot study

Francesco Fisicaro et al. Front Hum Neurosci. .

Abstract

Background: Sonographic mesenteric pattern in celiac disease (CD) suggests a hyperdynamic circulation. Despite the well-known CD-related neurological involvement, no study has systematically explored the cerebral hemodynamics to transcranial Doppler sonography.

Materials and methods: Montreal Cognitive Assessment (MoCA) and 17-item Hamilton Depression Rating Scale (HDRS) were assessed in 15 newly diagnosed subjects with CD and 15 age-, sex-, and education-matched healthy controls. Cerebral blood flow (CBF) velocities and indices of resistivity (RI) and pulsatility (PI) from the middle cerebral artery (MCA), bilaterally, and the basilar artery (BA) were recorded. We also assessed cerebral vasomotor reactivity (CVR) through the breath-holding test (BHT).

Results: Worse scores of MoCA and HDRS were found in patients compared to controls. Although patients showed higher values of CBF velocity from MCA bilaterally compared to controls, both at rest and after BHT, no comparison reached a statistical significance, whereas after BHT both RI and PI from BA were significantly higher in patients. A significant negative correlation between both indices from BA and MoCA score were also noted.

Conclusion: These treatment-naïve CD patients may show some subtle CVR changes in posterior circulation, thus possibly expanding the spectrum of pathomechanisms underlying neuroceliac disease and in particular gluten ataxia. Subclinical identification of cerebrovascular pathology in CD may help adequate prevention and early management of neurological involvement.

Keywords: celiac disease; cerebral blood flow; cerebral hemodynamics; cognition; depression; transcranial Doppler sonography; vasomotor reactivity.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

FIGURE 1
FIGURE 1
Spearman correlation analysis between Montreal cognitive assessment score (MoCA) and the resistivity index (top panel) and pulsatility index (bottom panel) from the basilar artery after the breath-holding test (BA-A-RI and BA-A-PI, respectively).
See this image and copyright information in PMC

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References

    1. Aaslid R., Lindegaard K. F., Sorteberg W., Nornes H. (1989). Cerebral autoregulation dynamics in humans. Stroke 20 45–52. 10.1161/01.str.20.1.45 - DOI - PubMed
    1. Adams R. J., McKie V. C., Carl E. M., Nichols F. T., Perry R., Brock K., et al. (1997). Long-term stroke risk in children with sickle cell disease screened with transcranial Doppler. Ann. Neurol. 42 699–704. 10.1002/ana.410420505 - DOI - PubMed
    1. Addolorato G., Giuda D. D., Rossi G. D., Valenza V., Domenicali M., Caputo F., et al. (2004). Regional cerebral hypoperfusion in patients with celiac disease. Am. J. Med. 116 312–317. 10.1016/j.amjmed.2003.09.037 - DOI - PubMed
    1. Alexandrov A. V., Grotta J. C. (2002). Arterial reocclusion in stroke patients treated with intravenous tissue plasminogen activator. Neurology 59 862–867. 10.1212/wnl.59.6.862 - DOI - PubMed
    1. Aliefendioglu D., Yilmaz S., Misirlioglu E. D., Saygi S., Ozdogan S., Kocak U. (2007). Do cerebral blood flow velocities change in iron deficiency anemia? J. Pediatr. Hematol. Oncol. 29 747–751. 10.1097/MPH.0b013e318157fd85 - DOI - PubMed