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Review
. 2022 Aug 21;18(14):5329-5344.
doi: 10.7150/ijbs.76134. eCollection 2022.

Autophagy-related Proteins in Genome Stability: Autophagy-Dependent and Independent Actions

Ye Zhang  1 , Ran Guo  2 , Shan-Shan Wang  1 , Xiao-You Jiang  1 , Hong-Yan Cui  1 , Yang Guo  1 , Xiao-Yu Song  1 , Qi-Qiang Guo  1 , Liu Cao  1
Affiliations
Review

Autophagy-related Proteins in Genome Stability: Autophagy-Dependent and Independent Actions

Ye Zhang et al. Int J Biol Sci. .

Abstract

It is emerging that autophagy-related proteins regulate the adaptive response to DNA damage in maintaining genome stability at multiple pathways. Here, we discuss recent insights into how autophagy-related proteins participate in DNA damage repair processes, influence chromosomal instability, and regulate the cell cycle through autophagy-dependent and independent actions. There is increasing awareness of the importance of these pathways mediated by autophagy-related proteins to DNA damage response (DDR), and disturbances in these regulatory connections may be linked to genomic instability participated in various human diseases, such as cancer and aging.

Keywords: Autophagy; Autophagy-related proteins; Genome Stability; Non-autophagic functions.

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Conflict of interest statement

Competing Interests: The authors have declared that no competing interest exists.

Figures

Figure 1
Figure 1
Schematic overview of autophagy-related proteins involved in regulation of the autophagic pathway.
Figure 2
Figure 2
Schematic overview of autophagy-related proteins involved in DNA damage through the autophagy pathway and non-autophagic pathway. (A) Autophagy related proteins involved in DNA damage through the autophagy dependent pathway. (B) Autophagy related proteins involved in DNA damage through the non- autophagic pathway.
Figure 3
Figure 3
Schematic of autophagy-related proteins involved in regulating chromosome stability through the autophagy pathway and non-autophagic pathway.
Figure 4
Figure 4
Schematic of autophagy related proteins involved in cell cycle regulation. (A) Autophagy related proteins involved in cell cycle regulation through the autophagy dependent pathway. (B) Autophagy related proteins involved in cell cycle regulation through the non- autophagic pathway.
See this image and copyright information in PMC

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