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. 2022 Aug 31:13:995630.
doi: 10.3389/fendo.2022.995630. eCollection 2022.

Blood immune indexes can predict lateral lymph node metastasis of thyroid papillary carcinoma

Lingqian Zhao  1 , Tianhan Zhou  2 , Wenhao Zhang  1 , Fan Wu  3 , Kecheng Jiang  1 , Bei Lin  1 , Siqi Zhan  1 , Tao Hu  1 , Tian Tang  1 , Yu Zhang  3 , Dingcun Luo  3
Affiliations

Blood immune indexes can predict lateral lymph node metastasis of thyroid papillary carcinoma

Lingqian Zhao et al. Front Endocrinol (Lausanne). .

Abstract

Objective: To explore the clinical significance of blood immune indexes in predicting lateral lymph node metastasis (LLNM) of thyroid papillary carcinoma (PTC).

Methods: The pathological data and preoperative blood samples of 713 patients that underwent thyroid surgery at affiliated Hangzhou First People's Hospital Zhejiang University School of Medicine from January 2013 to June 2021 were collected as the model group. The pathological data and preoperative blood samples of 177 patients that underwent thyroid surgery in the same hospital from July 2021 to October 2021 were collected as the external validation group. Univariate and multivariate logistic regression analyses were used to determine the independent risk factors of LLNM in PTC patients. A predictive model for assessing LLNM in PTC patients was established and externally validated using the external data.

Results: According to univariate and multivariate logistic regression analyses, tumor diameter (P < 0.001, odds ratios (OR): 1.205, 95% confidence interval (CI): 1.162-1.249) and the preoperative systemic immune-inflammation index (SII) (P = 0.032, OR: 1.001, 95% CI: 1.000-1.002) were independent risk factors for distinguishing LLNM in PTC patients. When the Youden index was the highest, the area under the curve (AUC) was 0.860 (P < 0.001, 95% CI: 0.821-0.898). The externally validated AUC was 0.827 (P < 0.001, 95% CI: 0.724-0.929), the specificity was 86.4%, and the sensitivity was 69.6%. The calibration curve and the decision curve indicated that the model had good diagnostic value.

Conclusion: Blood immune indexes can reflect the occurrence of LLNM and the biological behavior of PTC. The predictive model established in combination with SII and tumor diameter can effectively predict the occurrence of LLNM in PTC patients.

Keywords: lateral cervical lymph node; lymph node metastasis; nomogram; papillary thyroid carcinoma; systemic immune-inflammation index.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Clinical predictive model of lateral lymph node metastasis in papillary thyroid carcinoma patients.
Figure 2
Figure 2
Model group receiver operator characteristic curve.
Figure 3
Figure 3
Calibration curve.
Figure 4
Figure 4
Decision curve analysis.
Figure 5
Figure 5
Youden curve and cut-off point.
Figure 6
Figure 6
Validation group receiver operator characteristic curve.
See this image and copyright information in PMC

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