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. 2022 Oct;28(10):2100-2104.
doi: 10.3201/eid2810.220046.

Molecular Detection of Histoplasma capsulatum in Antarctica

Lucas Machado Moreira, Wieland Meyer, Márcia Chame, Martha Lima Brandão, Adriana Marcos Vivoni, Juana Portugal, Bodo Wanke, Luciana Trilles

Molecular Detection of Histoplasma capsulatum in Antarctica

Lucas Machado Moreira et al. Emerg Infect Dis. 2022 Oct.

Abstract

We detected Histoplasma capsulatum in soil and penguin excreta in the Antarctic Peninsula by sequencing after performing species-specific PCR, confirming previous observations that this pathogen occurs more broadly than suspected. This finding highlights the need for surveillance of emerging agents of systemic mycoses and their transmission among regions, animals, and humans in Antarctica.

Keywords: Antarctic regions; Antarctica; Histoplasma; fungi; histoplasmosis.

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Figures

Figure 1
Figure 1
Sampling locations for study of Histoplasma capsulatum in Antarctica. A) Location of the Antarctic Peninsula in the Antarctica continent; B) King George Island; C) Potter Peninsula and the Antarctic Specially Protected Area ASPA N°132. Source: SCAR Antarctic Digital Database (https://www.scar.org/resources/antarctic-digital-database).
Figure 2
Figure 2
Phylogenetic tree based on the 100-kDa–like protein partial gene sequences of Histoplasma capsulatum from Antarctica. The evolutionary history was inferred by using the maximum-likelihood method in in MEGA X software (https://www.megasoftware.net). This analysis involved 46 sequences: 5 from Antarctica samples and 41 representing geographic lineages of H. capsulatum in addition to the closest non-Histoplasma sequences (Blastomyces spp.) downloaded from GenBank (accession numbers shown). The bootstrap percentage of trees in which the associated taxa clustered together is shown next to the branches. Scale bar indicates the number of substitutions per site.
See this image and copyright information in PMC

References

    1. Deepe GS Jr. Outbreaks of histoplasmosis: The spores set sail. PLoS Pathog. 2018;14:e1007213. 10.1371/journal.ppat.1007213 - DOI - PMC - PubMed
    1. Knox KS, Hage CA. Histoplasmosis. Proc Am Thorac Soc. 2010;7:169–72. 10.1513/pats.200907-069AL - DOI - PubMed
    1. Teixeira MM, Patané JS, Taylor ML, Gómez BL, Theodoro RC, de Hoog S, et al. Worldwide phylogenetic distributions and population dynamics of the genus Histoplasma. PLoS Negl Trop Dis. 2016;10:e0004732. 10.1371/journal.pntd.0004732 - DOI - PMC - PubMed
    1. Kasuga T, White TJ, Koenig G, McEwen J, Restrepo A, Castañeda E, et al. Phylogeography of the fungal pathogen Histoplasma capsulatum. Mol Ecol. 2003;12:3383–401. 10.1046/j.1365-294X.2003.01995.x - DOI - PubMed
    1. Sepúlveda VE, Márquez R, Turissini DA, Goldman WE, Matute DR. Genome sequences reveal cryptic speciation in the human pathogen Histoplasma capsulatum. MBio. 2017;8:8. 10.1128/mBio.01339-17 - DOI - PMC - PubMed

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