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. 2022 Sep 25;55(1):162-164.
doi: 10.3724/abbs.2022134.

2-Aminoethoxydiphenyl-borate reduces arsenic-induced cardiotoxicity in rats

Wenjuan Qin, Jia Feng, Ruimeng Tian, Zhen Wang, Zijing Zhai, Guilin Lu, Shanshan Dong, Lei Huang

2-Aminoethoxydiphenyl-borate reduces arsenic-induced cardiotoxicity in rats

Wenjuan Qin et al. Acta Biochim Biophys Sin (Shanghai). .
No abstract available

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Conflict of interest statement

The authors declare that they have no conflict of interest.

Figures

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Figure 1
Effects of 2-APB on Bax and Bcl-2 levels in arsenic-induced cardiotoxicity in rats (A) Representative picture of myocardial HE staining in the control group. (B) Representative picture of myocardial HE staining in the NaAsO 2 group. (C) Representative picture of myocardial HE staining in the L-2-APB group. (D) Representative picture of myocardial HE staining in the H-2-APB group. Magnification, ×200. (E) Cleaved caspase-3 level detected by IHC staining. (F) Protein expression levels of Bax and Bcl-2 were measured by western blot analysis. (G) Relative expression of Bax was analyzed after normalizing to β-actin. (H) Relative expression of Bcl-2 was analyzed after normalizing to β-actin. a P<0.05 compared with the control group; b P<0.05 compared with the NaAsO 2 group; and c P<0.05 compared with the L-2-APB group.
None
Figure 2
Effects of 2-APB on CK-MB, LDH, SOD, GSH-px, MDA, and SERCA activities in rats with arsenic-induced cardiotoxicity Serum was collected from the control, NaAsO 2, L-2-APB, and H-2-APB groups and assayed for (A) CK-MB, (B) LDH, (C) SOD, (D) GSH-px, (E) MDA and (F) SERCA activities. CK-MB: creatine kinase myocardial band, LDH: lactate dehydrogenase, SOD: superoxide dismutase, GSH-px: glutathione peroxidase, MDA: malonic dialdehyde, SERCA: sarcoplasmic reticulum Ca 2+-ATPase. a P<0.05 compared with the control group; b P<0.05 compared with the NaAsO 2 group; and c P<0.05 compared with the L-2-APB group.
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