Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2022 Nov;600(21):4575-4578.
doi: 10.1113/JP282186. Epub 2022 Sep 23.

Cross Talk opposing view: Animal models of epilepsy are more useful than human tissue-based approaches

Amy Richardson  1 , Gareth Morris  2   3   4
Affiliations
Free article

Cross Talk opposing view: Animal models of epilepsy are more useful than human tissue-based approaches

Amy Richardson et al. J Physiol. 2022 Nov.
Free article
No abstract available

Keywords: Seizure; animal models; epilepsy; epileptogenesis; human tissue.

PubMed Disclaimer

Comment in

  • Rebuttal from Mark O. Cunningham.
    Cunningham MO. Cunningham MO. J Physiol. 2022 Nov;600(21):4579-4580. doi: 10.1113/JP283576. Epub 2022 Sep 23. J Physiol. 2022. PMID: 36149740 No abstract available.

References

    1. Carpenter, J. C., & Lignani, G. (2021). Gene editing and modulation: The holy grail for the genetic epilepsies? Neurotherapeutics, 18(3), 1515-1523.
    1. Deisseroth, K., Feng, G., Majewska, A. K., Miesenböck, G., Ting, A., & Schnitzer, M. J. (2006). Next-generation optical technologies for illuminating genetically targeted brain circuits. Journal of Neuroscience, 26(41), 10380-10386.
    1. Devinsky, O., Vezzani, A., Najjar, S., de Lanerolle, N. C., & Rogawski, M. A. (2013). Glia and epilepsy: Excitability and inflammation. Trends in Neurosciences, 36(3), 174-184.
    1. Ellender, T. J., Raimondo, J. V., Irkle, A., Lamsa, K. P., & Akerman, C. J. (2014). Excitatory effects of parvalbumin-expressing interneurons maintain hippocampal epileptiform activity via synchronous afterdischarges. Journal of Neuroscience, 34(46), 15208-15222.
    1. Goldberg, E. M., & Coulter, D. A. (2013). Mechanisms of epileptogenesis: A convergence on neural circuit dysfunction. Nature Reviews Neuroscience, 14(5), 337-349.

Publication types