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. 2022 Sep 16;79(3):254-259.
doi: 10.31053/1853.0605.v79.n3.36975.

[Prevalence of diarrhea in adult patients in intensive care and its relationship with ready-to-use enteral formulas]

[Article in Spanish]
Sebastián Chapela  1 , Pablo Ignacio Martinez  2 , María Jimena Reberendo  3 , Natalia Daniela Llobera  4 , Glenda Ernst  5
Affiliations

[Prevalence of diarrhea in adult patients in intensive care and its relationship with ready-to-use enteral formulas]

[Article in Spanish]
Sebastián Chapela et al. Rev Fac Cien Med Univ Nac Cordoba. .

Abstract
in English, Spanish

Introduction: Diarrhea is a frequent complication in critically ill patients. Its origin is multifactorial. The objective of this work is to analyze the relationship between 5 ready-to-use formulas and the development of diarrhea in critically ill patients.

Methods: Retrospective study where the volume of the stools of 315 patients and the presence of diarrhea defined with a cut-off point of a volume of 250 ml/day were evaluated. 35.34% of the patients presented diarrhea with said cut-off point. The mean volume of stools was 269.20 ml (95% CI: 255.05-283.06).

Results: It was observed that all the formulas analyzed had a slight correlation with the Spearman test between the volume provided and the volume of stools, being: Nutricia Nutrison ® (R: 0.159; P: 0.053), Nutricia Multifibra ® (R: 0.296; <0.001), Nutricia Peptisorb ® (R: 0.323; P<0.001), Nutricia Protison ® (R: 0.108; P<0.001), Fresenius Supportan ® (R: 0.152; P<0.001). Multivariate analysis was performed and it was observed that there were no differences in the incidence of diarrhea between the different enteral formulas during the first 10 days. The change of formulas during hospitalization would be a predisposing factor for diarrhea.

Conclusion: Therefore, the formula and the volume provided are factors that could influence whether patients have diarrhoea. Understanding these possible influences in a deeper way will allow the safest choice of enteral formulas for a patient with diarrhea.

Introducción: La diarrea es una complicación frecuente en los pacientes críticos. Su origen es multifactorial. El objetivo de este trabajo es analizar la relación entre 5 fórmulas listas para usar y el desarrollo de diarrea en pacientes críticos.

Métodos: Estudio retrospectivo donde se evaluó el volumen de las deposiciones de 315 pacientes y la presencia de diarrea definida con un punto de corte con un volumen de 250 ml/día.

Resultados: 35.34% de los pacientes presentaron diarrea con dicho punto de corte. El volumen medio de deposiciones fue de 269.20 ml (IC 95%: 255.05-283.06). Se observó que todas las fórmulas analizadas tenían una correlación leve con la prueba de spearman entre el volumen aportado y el volumen de las deposiciones, siendo: Nutricia Nutrison ® (R: 0.159; P: 0.053), Nutricia Multifibra ® (R: 0.296; <0.001), Nutricia Peptisorb ® (R: 0.323; P<0.001), Nutricia Protison ® (R: 0.108; P<0.001), Fresenius Supportan ® (R: 0.152; P<0.001). Se realizó análisis multivariado y se observó que no hubo diferencias en la incidencia de diarrea entre las distintas fórmulas enterales durante los primeros 10 días. La fibra soluble sería un factor protector en cambio la fibra mixta y semielemental serían factores que aumentan la incidencia de diarrea.

Conclusión: Por lo tanto, la fórmula y el volumen aportado son factores que podrían influenciar en que los pacientes tengan diarrea. Entendiendo estas posibles influencias de una manera mas profunda, permitirá elegir las formulas enterales con mas seguridad para un paciente con diarrea.

Keywords: diarrhea; nutrition, food and diet; critical care outcomes.

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Conflict of interest statement

Conflicto de interés:

Ninguno.

Figures

Figura Nº1
Figura Nº1. Correlación entre el volumen recibido de fórmulas enterales y volumen de deposiciones.
See this image and copyright information in PMC

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