Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Observational Study
. 2022 Sep 16;79(3):217-222.
doi: 10.31053/1853.0605.v79.n3.32403.

[Long-term results in patients with lung resections for colorectal cancer metastases. Experience of a single center in Argentina]

[Article in Spanish]
Soledad Belen Olivera Lopez  1 , Micaela Raices  2 , Luis Basbus  3 , Matias Cerini  4 , Nicolas Minatta  5 , Agustin Dietrich  6 , David Smith  7
Affiliations
Observational Study

[Long-term results in patients with lung resections for colorectal cancer metastases. Experience of a single center in Argentina]

[Article in Spanish]
Soledad Belen Olivera Lopez et al. Rev Fac Cien Med Univ Nac Cordoba. .

Abstract
in English, Spanish

Introduction: Between 5-10% of patients who undergo curative surgery for colorectal cancer (CRC) will present recurrence of their disease on the lungs. Surgical treatment of pulmonary metastases (PM) has gained popularity over the years, different publications report an overall survival rate at 5 years of between 30% and 60%. We present a review of patients with PM resections of CRC treated in a single center in Argentina.

Materials and methods: A descriptive, observational, retrospective study was conducted between 2008 and 2018. All patients with pulmonary metastasectomy of colorectal cancer were included. The primary endpoint was to evaluate overall survival and disease-free survival. Possible prognostic factors were evaluated as a secondary endpoint.

Results: A total of 99 surgeries were performed in the 68 patients, the resection was multiple in 48.5%, with more than 3 nodules in 13%. Overall and progression-free survival at 5 years was 55% and 27%, respectively. In the statistical analysis we found that the lesions in more than one lobe (p = 0.015) and the resection of more than 3 nodules (p = 0.011) presented a lower overall survival.

Conclusions: In this retrospective analysis we evidenced comparable values to the world literature regarding morbidity, mortality, overall survival and progression-free. In our series, patients with disease in more than one lobe or more than three resected lesions had significantly lower overall survival.

Introducción: Entre el 5-10% de los pacientes que se someten a cirugía curativa por cáncer colorrectal (CCR) presentarán en algún momento recurrencia de su enfermedad a nivel pulmonar. El tratamiento quirúrgico de las metástasis pulmonares (MP) fue ganando popularidad a través de los años, diferentes publicaciones informan una tasa de supervivencia global a los 5 años de entre 30% a 60%. Presentamos una revisión de pacientes con resecciones por MP de CCR tratados en un único centro en Argentina.

Materiales y métodos: Se realizó un estudio descriptivo, observacional, retrospectivo entre 2008 y 2018. Se incluyeron todos los pacientes con resecciones de MP de CCR. El objetivo primario fue evaluar la supervivencia global y supervivencia libre de enfermedad. Como objetivo secundario se evaluaron posibles factores pronósticos.

Resultados: Se realizaron un total de 99 cirugías en los 68 pacientes, la resección fue múltiple en un 48,5%, siendo más de 3 nódulos en un 13%. La supervivencia global y libre de progresión a los 5 años fue del 55% y del 27% respectivamente. En el análisis estadístico encontramos que las lesiones en más de un lóbulo (p=0.015) y la resección de más de 3 nódulos (p=0.011) presentaron una menor supervivencia global.

Conclusiones: En este análisis retrospectivo evidenciamos valores comparables a la literatura mundial con respecto a morbilidad, mortalidad, supervivencia global y libre de progresión. En nuestra serie los pacientes con enfermedad en más de un lóbulo o más de tres lesiones resecadas presentan significativamente menor supervivencia global.

Keywords: neoplasm metastasis; pulmonary surgical procedures; colorectal surgery.

PubMed Disclaimer

Conflict of interest statement

Conflictos de interés

Ninguno

Figures

Fig. 1
Fig. 1
Fig. 2
Fig. 2
Fig. 3
Fig. 3
See this image and copyright information in PMC

References

    1. Zink S, Kayser G, Gabius HJ, Kayser K. Survival, disease-free interval, and associated tumor features in patients with colon/rectal carcinomas and their resected intra-pulmonary metastases. Eur J Cardiothorac Surg. 2001 Jun;19(6):908–13. doi: 10.1016/s1010-7940(01)00724-2. - DOI - PubMed
    1. McCormack PM, Burt ME, Bains MS, Martini N, Rusch VW, Ginsberg RJ. Lung resection for colorectal metastases. 10-year results. Arch Surg. 1992 Dec;127(12):1403–6. doi: 10.1001/archsurg.1992.01420120037006. - DOI - PubMed
    1. Pihl E, Hughes ES, McDermott FT, Johnson WR, Katrivessis H. Lung recurrence after curative surgery for colorectal cancer. Dis Colon Rectum. 1987 Jun;30(6):417–9. doi: 10.1007/BF02556487. - DOI - PubMed
    1. Lee WS, Yun SH, Chun HK, Lee WY, Yun H. Clinical usefulness of chest radiography in detection of pulmonary metastases after curative resection for colorectal cancer. World J Surg. 2007 Jul;31(7):1502–6. doi: 10.1007/s00268-007-9060-0. - DOI - PubMed
    1. Thomford NR, Woolner LB, Clagett OT. The surgical treatment of metastatic tumors in the lungs. J Thorac Cardiovasc Surg. 1965;49:357–363. - PubMed

Publication types

LinkOut - more resources