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Review
. 2023 Jan;38(1):61-68.
doi: 10.1007/s11011-022-01082-6. Epub 2022 Sep 23.

Treatments against Polymorphosal discrepancies in Glioblastoma Multiforme

Nobendu Mukerjee  1   2 , Swastika Maitra #  3 , Subhradeep Roy  4 , Shaswata Modak  4 , Mohammad Mehedi Hasan  5 , Biswajit Chakraborty #  6 , Arabinda Ghosh  7 , Asmita Ghosh  8 , Mohammad Amjad Kamal  9   10   11   12 , Abhijit Dey  13 , Ghulam Md Ashraf  14   15 , Sumira Malik #  16 , Md Habibur Rahman  17 , Badrah S Alghamdi  14   18 , Adel Mohammad Abuzenadah  10   19 , Athanasios Alexiou #  20   21
Affiliations
Review

Treatments against Polymorphosal discrepancies in Glioblastoma Multiforme

Nobendu Mukerjee et al. Metab Brain Dis. 2023 Jan.

Abstract

Glioblastoma (GB) are aggressive tumors that obstruct normal brain function. While the skull cannot expand in response to cancer growth, the growing pressure in the brain is generally the first sign. It can produce more frequent headaches, unexplained nausea or vomiting, blurred peripheral vision, double vision, a loss of feeling or movement in an arm or leg, and difficulty speaking and concentrating; all depend on the tumor's location. GB can also cause vascular thrombi, damaging endothelial cells and leading to red blood cell leakage. Latest studies have revealed the role of single nucleotide polymorphisms (SNPs) in developing and spreading cancers such as GB and breast cancer. Many discovered SNPs are associated with GB, particularly in great abundance in the promoter region, creating polygenetic vulnerability to glioma. This study aims to compile a list of some of the most frequent and significant SNPs implicated with GB formation and proliferation.

Keywords: Epidermal growth factors receptor; Glioblastoma; Single nucleotide polymorphisms; Tumors.

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