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Comment
. 2022 Sep;12(9):e878.
doi: 10.1002/ctm2.878.

From spirometry to spatial omics in pursuit of asthma endotypes

Timothy S C Hinks  1
Affiliations
Comment

From spirometry to spatial omics in pursuit of asthma endotypes

Timothy S C Hinks. Clin Transl Med. 2022 Sep.
No abstract available

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Figures

FIGURE 1
FIGURE 1
Recent developments in clinical phenotyping, emerging ‘massively‐parallel’ technologies and bioinformatic analyses are accelerating the hunt for endotype‐specific mechanisms in severe asthma. ATAC, assay for transposase‐accessible chromatin; ELISA, enzyme‐linked immunosorbent assay; FeNO, fractional exhaled nitric oxide; PCA, principal component analysis; PCR, polymerase chain reaction; RNA, ribonucleic acid; sc, single cell; seq, sequencing; TDA, topological data analysis; UMAP, uniform manifold approximation and projection
See this image and copyright information in PMC

Comment on

  • Clinical and transcriptomic features of persistent exacerbation-prone severe asthma in U-BIOPRED cohort.
    Hoda U, Pavlidis S, Bansal AT, Takahashi K, Hu S, Ng Kee Kwong F, Rossios C, Sun K, Bhavsar P, Loza M, Baribaud F, Chanez P, Fowler SJ, Horvath I, Montuschi P, Singer F, Musial J, Dahlen B, Krug N, Sandstrom T, Shaw DE, Lutter R, Fleming LJ, Howarth PH, Caruso M, Sousa AR, Corfield J, Auffray C, De Meulder B, Lefaudeux D, Dahlen SE, Djukanovic R, Sterk PJ, Guo Y, Adcock IM, Chung KF; U-BIOPRED study group. Hoda U, et al. Clin Transl Med. 2022 Apr;12(4):e816. doi: 10.1002/ctm2.816. Clin Transl Med. 2022. PMID: 35474304 Free PMC article.

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