Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2022 Dec;37(12):5202-5206.
doi: 10.1111/jocs.16846. Epub 2022 Sep 23.

Understanding aortic valve repair through Ozaki procedure: A review of literature evidence

Jeremy Chan  1 , Ayan Basu  2 , Gabriela Di Scenza  2 , Jack Bartlett  3 , Ka Siu Fan  2 , Shwe Oo  1 , Amer Harky  4
Affiliations
Review

Understanding aortic valve repair through Ozaki procedure: A review of literature evidence

Jeremy Chan et al. J Card Surg. 2022 Dec.

Abstract

Background: Aortic valve neocuspidization (AV Neo) using glutaraldehyde-treated autologous pericardium was first reported by Ozaki et al. in 2007. This technique has become an alternative to tissue and mechanical valve in selected patients as long-term anticoagulation is not required and shows promising midterm results and durability.

Method: A comprehensive search was performed on the major database using the search terms "Ozaki technique" AND "Aortic Valve Neocuspidization" AND "AV Neocuspidization" AND "Autologous pericardium" AND "glutaraldehyde-treated autologous pericardium." Articles up to August 1st, 2021 were included in this study.

Results: A total of nine studies with a total of 1342 patients were included. The mean age was 67.36 and 54.23% were male. 66.32% and 23.92% of patients had aortic stenosis and aortic regurgitation, respectively. 66% of patients had a native tricuspid aortic valve (AV) and 31.37% of patients' native AV was bicuspid. Three studies reported their experience performing AV Neo via ministernotomy.

Conclusion: AV Neo can be a suitable alternative to surgical AV replacement in selected patients. The short- and midterm outcomes are comparable without the need for long-term oral anticoagulation. Long-term follow-up data are required for this novel approach to be widely adopted.

Keywords: Ozaki technique; aortic valve neocuspidization; literature review.

PubMed Disclaimer

References

REFERENCES

    1. Osnabrugge RL, Mylotte D, Head SJ, et al. Aortic stenosis in the elderly: disease prevalence and number of candidates for transcatheter aortic valve replacement: a meta-analysis and modeling study. J Am Coll Cardiol. 2013;62(11):1002-1012.
    1. Thoren O. Blood flow patterns of the forearm of critically ill post-traumatic patients. A plethysmographic study. Acta Chir Scand Suppl. 1974;443:1-59.
    1. Ozaki S, Kawase I, Yamashita H, et al. A total of 404 cases of aortic valve reconstruction with glutaraldehyde-treated autologous pericardium. J Thorac Cardiovasc Surg. 2014;147(1):301-306.
    1. Ozaki S, Kawase I, Yamashita H, Uchida S, Takatoh M, Kiyohara N. Midterm outcomes after aortic valve neocuspidization with glutaraldehyde-treated autologous pericardium. J Thorac Cardiovasc Surg. 2018;155(6):2379-2387.
    1. Marathe SP, Chavez M, Sleeper LA, Marx G, Del Nido PJ, Baird CW. Modified Ozaki procedure including annular enlargement for small aortic annuli in young patients. Ann Thorac Surg. 2020;110(4):1364-1371.

LinkOut - more resources