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. 2023 Jan;20(1):1-28.
doi: 10.1007/s10388-022-00950-5. Epub 2022 Sep 24.

Comprehensive registry of esophageal cancer in Japan, 2015

Masayuki Watanabe  1 , Yasushi Toh  2 , Ryu Ishihara  3 , Koji Kono  4 , Hisahiro Matsubara  5 , Tatsuya Miyazaki  6 , Masaru Morita  2 , Kentaro Murakami  5 , Kei Muro  7 , Hodaka Numasaki  8 , Tsuneo Oyama  9 , Hiroshi Saeki  10 , Koji Tanaka  11 , Takahiro Tsushima  12 , Masaki Ueno  13 , Takashi Uno  14 , Toshiyuki Yoshio  15 , Shiyori Usune  16 , Arata Takahashi  16 , Hiroaki Miyata  16 ; Registration Committee for Esophageal Cancer of the Japan Esophageal Society
Affiliations

Comprehensive registry of esophageal cancer in Japan, 2015

Masayuki Watanabe et al. Esophagus. 2023 Jan.

Abstract

Background: The registration committee for esophageal cancer in the Japan Esophageal Society (JES) has collected the patients' characteristics, treatment, and outcomes of patients who underwent any treatment during 2015 in Japan.

Methods: We analyzed patients' data who had visited the participating hospitals in 2015. We collected the data using the National Clinical Database with a web-based data collection system. We used the Japanese Classification of Esophageal Cancer 10th edition by JES and the TNM classification by the Union of International Cancer Control (UICC) for cancer staging.

Results: A total of 9368 cases were registered from 355 institutions in Japan. Squamous cell carcinoma and adenocarcinoma accounted for 86.7% and 7.4%, respectively. The 5-year survival rates of patients treated by endoscopic resection, concurrent chemoradiotherapy, radiotherapy alone, and esophagectomy were 87.2%, 33.5%, 24.2%, and 59.9%, respectively. Esophagectomy was performed in 5172 cases. Minimally invasive approaches were selected for 60.6%, and 54.4% underwent thoracoscopic esophagectomy. The operative mortality (within 30 days after surgery) was 0.79% and the hospital mortality was 2.3%. The survival curves showed an excellent discriminatory ability both in the clinical and pathologic stages by the JES system. The survival of pStage IV was better than IIIC in the UICC system because pStage IV included the patients with supraclavicular lymph node metastasis (M1 LYM).

Conclusion: We hope this report improves all aspects of diagnosing and treating esophageal cancer in Japan.

Keywords: Cancer registry; Chemoradiotherapy; Chemotherapy; Endoscopic resection; Esophageal cancer; Esophagectomy.

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Conflict of interest statement

Shiyori Usune, Arata Takahashi, and Hiroaki Miyata are affiliated with the Department of Healthcare Quality Assessment at the University of Tokyo. The department is a social collaboration department supported by grants from the National Clinical Database, Johnson & Johnson K.K., Nipro Co, and Intuitive Surgical Sàrl. Other authors have no conflict of interest.

Figures

Fig. 1
Fig. 1
Survival of patients treated with EMR/ESD
Fig. 2
Fig. 2
Survival of patients treated with EM/ESD according to the pathological depth of tumor invasion, pT (JES 10th)
Fig. 3
Fig. 3
Survival of patients treated with EMR/ESD according to the lymphatic and venous invasion
Fig. 4
Fig. 4
Survival of patients treated with chemotherapy and/or radiotherapy
Fig. 5
Fig. 5
Survival of patients treated with definitive chemoradiotherapy according to the clinical stage (UICC TNM 7th)
Fig. 6
Fig. 6
Survival of patients who underwent radiotherapy alone according to the clinical stage (UICC TNM 7th)
Fig. 7
Fig. 7
Survival of patients who underwent esophagectomy
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Fig. 8
Survival of patients who underwent esophagectomy according to the clinical stage (JES 10th)
Fig. 9
Fig. 9
Survival of patients who underwent esophagectomy according to the clinical stage (UICC TNM 7th)
Fig. 10
Fig. 10
Survival of patients who underwent esophagectomy according to the depth of tumor invasion, pT (JES 10th)
Fig. 11
Fig. 11
Survival of patients who underwent esophagectomy according to lymph-node metastasis (JES 10th)
Fig. 12
Fig. 12
Survival of patients who underwent esophagectomy according to lymph-node metastasis (UICC TNM 7th)
Fig. 13
Fig. 13
Survival of patients who underwent esophagectomy according to the pathological stage (JES 10th)
Fig. 14
Fig. 14
Survival of patients who underwent esophagectomy according to the pathological stage (UICC TNM 7th)
Fig. 15
Fig. 15
Survival of patients
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