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. 2022 Dec;28(12):2260-2267.
doi: 10.1111/cns.13972. Epub 2022 Sep 24.

Higher fasting blood glucose was associated with worse in-hospital clinical outcomes in patients with primary intracerebral hemorrhage: From a large-scale nationwide longitudinal registry

Guangshuo Li  1 , Shang Wang  2 , Yunyun Xiong  1   3   4 , Hongqiu Gu  4 , Yingyu Jiang  4 , Xin Yang  4   5 , Chunjuan Wang  4   5 , Chuanying Wang  1 , Zixiao Li  1   3   4 , Xingquan Zhao  1   4
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Higher fasting blood glucose was associated with worse in-hospital clinical outcomes in patients with primary intracerebral hemorrhage: From a large-scale nationwide longitudinal registry

Guangshuo Li et al. CNS Neurosci Ther. 2022 Dec.

Abstract

Introduction: Studies that investigated the relationship between fasting blood glucose (FBG) and intracerebral hemorrhage (ICH) outcomes were insufficient.

Aim: We aimed to investigate the association between FBG level and in-hospital clinical outcomes in patients with primary ICH.

Results: A total of 34,507 patients were enrolled in the final study. Compared with the reference group, the ≥6.1 and <7 mmol/L group showed nonsignificant higher in-hospital mortality (adjusted odds ratio [OR] 1.20, 95% confidence interval [CI] 0.69-2.11, p = 0.52), and a significant higher proportion of intracranial hematoma evacuation (adjusted OR 1.56, 95% CI 1.26-1.92, p < 0.001). The ≥7 mmol/L group showed both significant higher in-hospital mortality (adjusted OR 2.08, 95% CI 1.42-3.04, p = 0.52) and a significant higher proportion of intracranial hematoma evacuation (adjusted OR 2.09, 95% CI 1.78-2.47, p < 0.001).

Conclusion: Higher FBG level was correlated with both higher mortality and proportion of evacuation of intracranial hematoma.

Keywords: cerebral hemorrhage; glucose; mortality; outcome.

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Conflict of interest statement

The authors declare that they have no competing interests.

Figures

FIGURE 1
FIGURE 1
Flow chart
FIGURE 2
FIGURE 2
Forest plots of in‐hospital outcomes. FBG, fasting blood glucose. Adjusted for age, male, GCS score, medical history, LDL‐c, total cholesterol, triglyceride, HbA1c, systolic blood pressure and diastolic blood pressure
FIGURE 3
FIGURE 3
Restricted cubic splines to delineate the relationship between FBG and adjusted OR for (A) in‐hospital mortality, and (B) evacuation of intracranial hematoma. Adjusted for age, male, GCS score, medical history, LDL‐c, total cholesterol, triglyceride, HbA1c, systolic blood pressure and diastolic blood pressure
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