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Multicenter Study
. 2022 Nov 1;58(5):358-365.
doi: 10.1097/SHK.0000000000001994. Epub 2022 Sep 8.

INCIDENCE, RISK FACTORS, AND OUTCOME OF SUSPECTED CENTRAL VENOUS CATHETER-RELATED INFECTIONS IN CRITICALLY ILL COVID-19 PATIENTS: A MULTICENTER RETROSPECTIVE COHORT STUDY

Jasper M Smit, Lotte Exterkate  1 , Arne J van Tienhoven  2 , Mark E Haaksma, Micah L A Heldeweg, Lucas Fleuren  1 , Patrick Thoral  1 , Tariq A Dam  1 , Leo M A Heunks  3 , Diederik Gommers  3 , Olaf L Cremer  4 , Rob J Bosman  2 , Sander Rigter  5 , Evert-Jan Wils  6 , Tim Frenzel  7 , Alexander P Vlaar  8 , Dave A Dongelmans  8 , Remko de Jong  9 , Marco Peters  10 , Marlijn J A Kamps  11 , Dharmanand Ramnarain  12 , Ralph Nowitzky  13 , Fleur G C A Nooteboom  14 , Wouter de Ruijter  15 , Louise C Urlings-Strop  16 , Ellen G M Smit  17 , D Jannet Mehagnoul-Schipper  18 , Tom Dormans  19 , Cornelis P C de Jager  20 , Stefaan H A Hendriks  21 , Sefanja Achterberg  22 , Evelien Oostdijk  23 , Auke C Reidinga  24 , Barbara Festen-Spanjer  25 , Gert B Brunnekreef  26 , Alexander D Cornet  27 , Walter van den Tempel  28 , Age D Boelens  29 , Peter Koetsier  30 , Judith Lens  31 , Harald J Faber  32 , A Karakus  33 , Robert Entjes  34 , Paul de Jong  35 , Thijs C D Rettig  36 , Sesmu Arbous  37 , Bas Vonk  38 , Tomas Machado  38 , Armand R J Girbes  1 , Elske Sieswerda  39 , Paul W G Elbers  1 , Pieter R Tuinman
Affiliations
Multicenter Study

INCIDENCE, RISK FACTORS, AND OUTCOME OF SUSPECTED CENTRAL VENOUS CATHETER-RELATED INFECTIONS IN CRITICALLY ILL COVID-19 PATIENTS: A MULTICENTER RETROSPECTIVE COHORT STUDY

Jasper M Smit et al. Shock. .

Abstract

Background: Aims of this study were to investigate the prevalence and incidence of catheter-related infection, identify risk factors, and determine the relation of catheter-related infection with mortality in critically ill COVID-19 patients. Methods: This was a retrospective cohort study of central venous catheters (CVCs) in critically ill COVID-19 patients. Eligible CVC insertions required an indwelling time of at least 48 hours and were identified using a full-admission electronic health record database. Risk factors were identified using logistic regression. Differences in survival rates at day 28 of follow-up were assessed using a log-rank test and proportional hazard model. Results: In 538 patients, a total of 914 CVCs were included. Prevalence and incidence of suspected catheter-related infection were 7.9% and 9.4 infections per 1,000 catheter indwelling days, respectively. Prone ventilation for more than 5 days was associated with increased risk of suspected catheter-related infection; odds ratio, 5.05 (95% confidence interval 2.12-11.0). Risk of death was significantly higher in patients with suspected catheter-related infection (hazard ratio, 1.78; 95% confidence interval, 1.25-2.53). Conclusions: This study shows that in critically ill patients with COVID-19, prevalence and incidence of suspected catheter-related infection are high, prone ventilation is a risk factor, and mortality is higher in case of catheter-related infection.

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Conflict of interest statement

The authors report no conflicts of interest.

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