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. 2022 Sep 8:10:932902.
doi: 10.3389/fchem.2022.932902. eCollection 2022.

Synthesis of efficient cobalt-metal organic framework as reusable nanocatalyst in the synthesis of new 1,4-dihydropyridine derivatives with antioxidant activity

Omar Dheyauldeen Salahdin  1 , Indrajit Patra  2 , Mohammad Javed Ansari  3 , Samar Emad Izzat  4 , Khusniddin Fakhriddinovich Uktamov  5 , Mohammed Kadhem Abid  6 , Ahmed B Mahdi  7 , Ali Thaeer Hammid  8 , Yasser Fakri Mustafa  9 , Himanshu Sharma  10
Affiliations

Synthesis of efficient cobalt-metal organic framework as reusable nanocatalyst in the synthesis of new 1,4-dihydropyridine derivatives with antioxidant activity

Omar Dheyauldeen Salahdin et al. Front Chem. .

Retraction in

Abstract

Efficient cobalt-metal organic framework (Co-MOF) was prepared via a controllable microwave-assisted reverse micelle synthesis route. The products were characterized by SEM image, N2 adsorption/desorption isotherm, FTIR spectrum, and TG analysis. Results showed that the products have small particle size distribution, homogenous morphology, significant surface area, and high thermal stability. The physicochemical properties of the final products were remarkable compared with other MOF samples. The newly synthesized nanostructures were used as recyclable catalysts in the synthesis of 1,4-dihydropyridine derivatives. After the confirmation of related structures, the antioxidant activity of derivatives based on the DPPH method was evaluated and the relationship between structures and antioxidant activity was observed. In addition to recyclability, the catalytic activity of Co-MOF studied in this research has remarkable effects on the synthesis of 1,4 dihydropyridine derivatives.

Keywords: DPPH method; antioxidant activity; catalytic activity; cobalt–metal organic framework; dihydropyridine.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

FIGURE 1
FIGURE 1
Structure of Alzheimer’s disease drugs contain 1,4-dihydropyridine.
FIGURE 2
FIGURE 2
Thermal curve (A), SEM image (B), N2 adsorption/desorption behaviour (C) and XRD patterns of Co-MOF nanostructures synthesized by microwave assisted reverse micelle route (D).
FIGURE 3
FIGURE 3
FTIR spectrum of Co-MOF nanostructures synthesized by microwave assisted reverse micelle route.
FIGURE 4
FIGURE 4
Suggested formula for Co-MOF nanostructures synthesized by microwave assisted reverse micelle route.
SCHEME 1
SCHEME 1
Synthesis 1,4-dihydropyridine derivative by Co-MOF nanostructures.
SCHEME 2
SCHEME 2
Proposed mechanism for the synthesis 1,4-dihydropyridine derivative by Co-MOF nanostructures.
FIGURE 5
FIGURE 5
Reusability of Co-MOF nanostructures in synthesis 1,4-dihydropyridine derivatives.
FIGURE 6
FIGURE 6
Proposed mechanism for radical stability of DPPH by 1,4-dihydropyridine derivatives.
See this image and copyright information in PMC

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References

    1. Aghaei-Hashjin M., Yahyazadeh A., Abbaspour-Gilandeh E. (2021). Mo@ GAA-Fe3O4 MNPs: a highly efficient and environmentally friendly heterogeneous magnetic nanocatalyst for the synthesis of polyhydroquinoline derivatives. RSC Adv. 11, 10497–10511. 10.1039/d1ra00396h - DOI - PMC - PubMed
    1. Al-Attri R., Halladj R., Askari S. (2022). Green route of flexible Al-MOF synthesis with superior properties at low energy consumption assisted by ultrasound waves. Solid State Sci. 123, 106782. 10.1016/j.solidstatesciences.2021.106782 - DOI
    1. Al-Rowaili F. N., Jamal A., Ba Shammakh M. S., Rana A. (2018). A review on recent advances for electrochemical reduction of carbon dioxide to methanol using metal–organic framework (MOF) and non-MOF catalysts: challenges and future prospects. ACS Sustain. Chem. Eng. 6, 15895–15914. 10.1021/acssuschemeng.8b03843 - DOI
    1. Ali El-Remaily M. A. E. A. A., Hamad H. A., Soliman A. M., Elhady O. M. (2021). Boosting the catalytic performance of manganese (III)-porphyrin complex MnTSPP for facile one-pot green synthesis of 1, 4-dihydropyridine derivatives under mild conditions. Appl. Organomet. Chem. 35, e6238. 10.1002/aoc.6238 - DOI
    1. Anaikutti P., Makam P. (2020). Dual active 1, 4-dihydropyridine derivatives: design, green synthesis and in vitro anti-cancer and anti-oxidant studies. Bioorg. Chem. 105, 104379. 10.1016/j.bioorg.2020.104379 - DOI - PubMed

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