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Review
. 2022 Sep 8:13:994930.
doi: 10.3389/fendo.2022.994930. eCollection 2022.

Roles of gut microbiota and metabolites in overweight and obesity of children

Shengan Zhang  1   2 , Yanqi Dang  1
Affiliations
Review

Roles of gut microbiota and metabolites in overweight and obesity of children

Shengan Zhang et al. Front Endocrinol (Lausanne). .

Abstract

The prevalence of overweight and obesity in children and adolescents is an increasing public health problem. Pediatric overweight and obesity result from multiple factors, including genetic background, diet, and lifestyle. In addition, the gut microbiota and their metabolites play crucial roles in the progression of overweight and obesity of children. Therefore, we reviewed the roles of gut microbiota in overweight/obese children. The relationship between pediatric overweight/obesity and gut metabolites, such as short-chain fatty acids, medium-chain fatty acids, amino acids, amines, and bile acids, are also summarized. Targeting gut microbiota and metabolites might be a promising strategy for interventions aimed at reducing pediatric overweight/obesity.

Keywords: children; gut microbiota; metabolites; obesity; overweight.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
The relationship and molecular signaling between gut microbiota and their metabolites with obesity.
Figure 2
Figure 2
Relationship between gut metabolites (amino acids, amines, and bile acids) and pediatric overweight/obesity.
See this image and copyright information in PMC

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