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Review
. 2022 Jun 18;9(6):1493-1505.
doi: 10.1016/j.gendis.2022.05.038. eCollection 2022 Nov.

Therapeutic potential for targeting Annexin A1 in fibrotic diseases

Zhibin Yan  1 , Xurui Cheng  1 , Tao Wang  1 , Xiangyu Hong  1 , Gang Shao  2 , Caiyun Fu  1
Affiliations
Review

Therapeutic potential for targeting Annexin A1 in fibrotic diseases

Zhibin Yan et al. Genes Dis. .

Abstract

Annexin A1, a well-known endogenous anti-inflammatory mediator, plays a critical role in a variety of pathological processes. Fibrosis is described by a failure of tissue regeneration and contributes to the development of many diseases. Accumulating evidence supports that Annexin A1 participates in the progression of tissue fibrosis. However, the fundamental mechanisms by which Annexin A1 regulates fibrosis remain elusive, and even the functions of Annexin A1 in fibrotic diseases are still paradoxical. This review focuses on the roles of Annexin A1 in the development of fibrosis of lung, liver, heart, and other tissues, with emphasis on the therapy potential of Annexin A1 in fibrosis, and presents future research interests and directions in fibrotic diseases.

Keywords: Annexin A1; Anti-inflammatory; Fibrosis; Fibrotic diseases; Sequence alignment.

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Figures

Figure 1
Figure 1
The profile of Annexin A family. (A) Schematic overview of Annexins. The long columns of different colors represent Annexin repeats. (B) The Neighbor-Joining phylogenetic tree of Annexin proteins family was performed by using MEGA software vs 11.0.8. (C) The three-dimensional structure diagrams of the one monomer of full-length human Annexin A1 in the presence of calcium ions (PDB code: 1MCX). Bound calcium ions are illustrated as orange spheres. 3D-structures are visualized with the PyMOL software vs. 2.24.6.
Figure 2
Figure 2
Protein sequence alignment of Annexin A family members. Multiple sequences alignment of Annexin A1-13 proteins was performed by using Jalview software vs 2.11.1.4.
Figure 3
Figure 3
Schematic representation of Annexin A1 in inhibiting inflammation.
Figure 4
Figure 4
The signaling pathways associated with the anti-inflammatory effects of Annexin A1 and Ac2-26.
Figure 5
Figure 5
Annexin A1 and fibrotic diseases.
See this image and copyright information in PMC

References

    1. Rosenbloom J., Macarak E., Piera-Velazquez S., Jimenez S.A. Human fibrotic diseases: current challenges in fibrosis research. Methods Mol Biol. 2017;1627:1–23. - PubMed
    1. Zhu H., Zhao H., Xu S., et al. Sennoside A alleviates inflammatory responses by inhibiting the hypermethylation of SOCS1 in CCl4-induced liver fibrosis. Pharmacol Res. 2021;174:105926. - PubMed
    1. Peng L., Agogo G.O., Guo J., Yan M. Substance P and fibrotic diseases. Neuropeptides. 2019;76:101941. - PubMed
    1. Distler J.H.W., Györfi A.H., Ramanujam M., Whitfield M.L., Königshoff M., Lafyatis R. Shared and distinct mechanisms of fibrosis. Nat Rev Rheumatol. 2019;15(12):705–730. - PubMed
    1. Wynn T.A., Ramalingam T.R. Mechanisms of fibrosis: therapeutic translation for fibrotic disease. Nat Med. 2012;18(7):1028–1040. - PMC - PubMed

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