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Meta-Analysis
. 2022 Sep 14:2022:1126616.
doi: 10.1155/2022/1126616. eCollection 2022.

The Association of Sperm DNA Fragment and Assisted Reproductive Outcomes: A Meta-Analysis

Yue Chen  1 , Wei Li  2 , Xin Chen  3
Affiliations
Meta-Analysis

The Association of Sperm DNA Fragment and Assisted Reproductive Outcomes: A Meta-Analysis

Yue Chen et al. Comput Math Methods Med. .

Abstract

Objective: To analyze the effect of sperm DNA fragmentation index (DFI) on the outcomes of in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI).

Methods: Literature search was conducted on English databases PubMed, Cochrane, and Embase to obtain eligible studies.

Results: A total of 11 cohort studies were included and analyzed using the random effects model. The results illustrated that the IVF fertilization rate (RR = 0.94, 95% CI: 0.77-1.14, P = 0.61), pregnancy rate (RR = 0.83, 95% CI: 0.57-1.21, P = 0.32), and live birth rate (RR = 0.53, 95% CI: 0.16-1.80, P = 0.31) in the high DFI group were statistically insignificant with those in the low FI group. The correlations between DFI and ICSI fertilization rate (RR = 0.79, 95% CI: 0.52-1.18, P = 0.25), pregnancy rate (RR = 0.89, 95% CI: 0.74-1.06, P = 0.18), and live birth rate (RR = 0.89, 95% CI: 0.70-1.14, P = 0.36) were also not statistically significant.

Conclusion: This study has observed no significant correlation between sperm DFI and assisted reproductive outcomes. Multicenter large-sample clinical trials are required to conclusively determine the impact of DNA damage on the clinical outcomes of assisted reproduction.

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Conflict of interest statement

The authors declare that there are no conflicts of interest regarding the publication of this paper.

Figures

Figure 1
Figure 1
Document screening process and results.
Figure 2
Figure 2
Correlation between DFI and IVF fertilization rate.
Figure 3
Figure 3
Correlation between DFI and IVF pregnancy rate.
Figure 4
Figure 4
Correlation between DFI and IVF live birth rate.
Figure 5
Figure 5
Correlation between DFI and ICSI fertilization rate.
Figure 6
Figure 6
Correlation between DFI and ICSI pregnancy rate.
Figure 7
Figure 7
Correlation between DFI and ICSI live birth rate.
Figure 8
Figure 8
Funnel diagram of the correlation between DFI and IVF fertilization rate.
Figure 9
Figure 9
Funnel diagram of the correlation between DFI and IVF pregnancy rate.
Figure 10
Figure 10
Funnel diagram of the correlation between DFI and ICSI fertilization rate.
Figure 11
Figure 11
Funnel diagram of a correlation between DFI and ICSI pregnancy rate.
See this image and copyright information in PMC

References

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