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Randomized Controlled Trial
. 2022 Sep 14:2022:9277847.
doi: 10.1155/2022/9277847. eCollection 2022.

Correlation Analysis of Serum Pepsinogen, Interleukin, and TNF- α with Hp Infection in Patients with Gastric Cancer: A Randomized Parallel Controlled Clinical Study

Shunxin Hao  1 , Minyue Shou  2 , Jing Ma  3 , Yongqian Shu  2 , Yuanyuan Yu  4
Affiliations
Randomized Controlled Trial

Correlation Analysis of Serum Pepsinogen, Interleukin, and TNF- α with Hp Infection in Patients with Gastric Cancer: A Randomized Parallel Controlled Clinical Study

Shunxin Hao et al. Comput Math Methods Med. .

Retraction in

Abstract

Background: Gastric cancer pathological biopsy and visual examination have been the gold standard for gastric cancer diagnosis, but their operation is costly, demanding, and risky, so it is especially important to find an effective examination method in clinical practice.

Aims: To investigate the correlation between serum pepsinogen I (PGI), pepsinogen II (PGII), pepsinogen I and II ratio (PGR), IL-6, and TNF-α and Helicobacter pylori (Hp) infection in patients with gastric cancer.

Materials and methods: Fifty patients with Hp-infected gastric cancer admitted to the Department of Gastroenterology of our hospital from January 2019 to December 2021 were selected for the study as the observation group, and another 50 patients without Hp-infected gastric cancer were selected as the comparison group to compare the correlation analysis of PGI, PGII, PGR, IL-6, and TNF-α with Hp infection between the two groups after admission and treatment.

Results: After measurement, PGI and PGII in the observation group were significantly lower than those in the comparison group, and TNF-α, IL-18, and IL-6 in the observation group were significantly higher than those in the comparison group, and the comparative differences were all statistically significant (P < 0.05). The results of multivariate logistic regression model analysis of independent risk factors for gastric cancer showed that IL-18, hs-CRP, and tumor necrosis factor- (TNF-) α were risk factors for Hp infection in gastric cancer.

Conclusion: The expression of IL-18, hs-CRP, and TNF-α factors in Hp-infected gastric cancer patients is correlated. IL-6, IL-18, and TNF-α are involved in the entire process from the onset to the development of Hp-positive gastric mucosal inflammation in patients, which is of great value in the diagnosis of gastric cancer and helps to assess the degree of progression and prognosis of gastric cancer.

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Conflict of interest statement

There are no conflicts of interest.

Figures

Figure 1
Figure 1
Comparison of serum indicators. In this study, the statistics of the pain VAS scores of the two groups of patients were entered into Excel software by the first and corresponding author, respectively, and the included data were tested using the Shapiro-Wilk method of mean ± standard deviation of the measured data conforming to a normal distribution. And independent sample or paired sample t-tests were implemented between or within groups. PGI and PGII in the observation group were significantly lower than those in the comparison group, and TNF-α, IL-18, and IL-6 in the observation group were significantly higher than those in the comparison group, and the comparative differences were all statistically significant (P < 0.05).
Figure 2
Figure 2
Comparison of gastric cancer staging and related indicators. In this study, statistics of pain VAS scores for both groups were entered into Excel software by the first and corresponding authors, respectively, and measures of gastrin-17, CEA, CA199, PGI, and PGI/PGII were tested for inclusion by the Shapiro-Wilk method of mean ± standard deviation. And independent sample or paired sample t-tests were implemented between or within groups, and HP-positive rate count data were expressed as whole numbers and found by chi-square test. Higher clinical stage of gastric cancer resulted in higher serum gastrin-17, CEA, and CA199 levels and lower PGI levels, all with statistically significant differences in comparison (P < 0.05). However, the differences in PGI/PGII and HP-positive rates were not statistically significant in patients with different gastric cancer stages (P > 0.05).
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