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Case Reports
. 2022 Sep 15:18:100350.
doi: 10.1016/j.lrr.2022.100350. eCollection 2022.

Acute myeloid leukemia with variant t(8;10;21)

Barbora Bacova  1 , Jiri Sobotka  2 , Petra Kacirkova  3 , Veronika Rivnacova  1 , Ivana Karlova/Zubata  1 , Jan Novak  1   4
Affiliations
Case Reports

Acute myeloid leukemia with variant t(8;10;21)

Barbora Bacova et al. Leuk Res Rep. .

Abstract

The t(8;21)(q22;q22) is one of the most common chromosomal abnormalities in acute myeloid leukemia (AML). Approximately 3-4% of AML cases are associated with additional chromosomal abnormalities. Their impact on the prognosis of the disease remains to be established. Here we report a case of t(8;10;21) AML with mutated c-KIT that shared key morphological features with classical t(8;21) leukemias, including the M2 morphology pattern and CD34, HLA-DR phenotype. The 63-year-old female was treated with two inductioncontaining Daunoribicine and Cytarabine and four cycles of intermediate-dose Cytarabine (1.5 g/m2) and achieved long-lasting remission.

Keywords: 21); Acute myeloid leukemia; Cytogenetics; Fluorescence in situ hybridization; t(8.

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Conflict of interest statement

The research has been performed in accordance with the Declaration of Helsinki. All data generated or analysed during this study are included in this published article. The authors declare that they have no competing interests. The work was supported by the research project Q28-PROGRES awarded by the 3rd Faculty of Medicine, Charles University, Czech Republic. The funding body had no role in the design of the study, the collection, analysis, and interpretation of data, nor in the writing of the manuscript.

Figures

Fig 1
Fig. 1
The bone marrow aspirate. The bone marrow aspirate smears were hypercellular, with massive (66%) infiltration by myeloblasts. The myeloblast varied in diameter between 12–16 μm, and had round nuclei with one to four nucleoli and fine nuclear chromatin. The cytoplasm was scanty, moderately basophilic, often containing azurophilic granules and sporadic Auer rod or pseudo-Chédiak-Higashi inclusion. The proportion of promyelocytes was also elevated (9%), often having atypically shaped nuclei and granulation defects. More mature granulocytes were also often dysplastic – hypogranularity, agranularity, and unusually small myelocytes as well as pelgeroid changes were present. Erythropoiesis and megakaryopoiesis almost were absent.
Fig 2
Fig. 2
A. Routine cytogenetic analysis. Routine cytogenetic analysis revealed complex chromosomal changes involving three chromosomes: 8, 10, and 21. B. FISH analysis. Using a dual-color, dual-fusion RUNX1-RUNX1T1 probe revealed a specific RUNX1-RUNX1T1 fusion signal on the derivative chromosome 8.
See this image and copyright information in PMC

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