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. 2022 Nov:168:110953.
doi: 10.1016/j.mehy.2022.110953. Epub 2022 Sep 21.

Plasma fibrinogen: An important piece of the COVID-19 ICU delirium puzzle?

Sarah Saxena  1 , Alexandre-Raphael Wery  2 , Adrian Khelif  2 , Marie-Laure Nisolle  3 , Christophe Lelubre  4 , Mervyn Maze  5 , Patrick Biston  2 , Michael Piagnerelli  2   6
Affiliations

Plasma fibrinogen: An important piece of the COVID-19 ICU delirium puzzle?

Sarah Saxena et al. Med Hypotheses. 2022 Nov.
No abstract available

Keywords: ARDS, Acute Respiratory Distress Syndrome; BBB, Blood Brain Barrier; CNS, Central Nervous System; Delirium; Fibrinogen; ICU, Intensive Care Unit; IQR, Interquartile Ranges; RASS, Richmond Agitation Sedation Scale; ROC, Receiver Operating; SARS-COV2; SE, Standard Error.

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Conflict of interest statement

The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Figures

Fig. 1
Fig. 1
Fibrin mechanisms and functions in neuroinflammation. Upon BBB disruption, fibrinogen leaks into the brain, and, by activation of the coagulation cascade, it is converted to insoluble fibrin deposits. Fibrin activates microglia and induces the release of CXCL10 and MCP1 to promote recruitment of peripheral immune cells, as well as activation of NADP oxidase to induce oxidative injury, leading to tissue damage. Inhibition of the interaction of fibrin with its cellular receptors or suppression of fibrin's downstream signaling pathways in cells could enable the discovery of selective therapies to the toxic effects of blood leaks in a wide range of diseases that cause vascular damage and inflammation.
Fig. 2
Fig. 2
Box plot and violin plot for plasma fibrinogen levels at ICU admission in patients with or without confusion/ agitation during ICU stay. Dashed lines denote lower and upper laboratory limits for plasma fibrinogen (2.0–4.5 g/L). Groups were compared using a Wilcoxon test for unpaired data. * denotes a p-value < 0.05 .
See this image and copyright information in PMC

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