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. 2022 Sep 9:14:919430.
doi: 10.3389/fnagi.2022.919430. eCollection 2022.

Serum creatinine to cystatin C ratio and cognitive function among middle-aged and older adults in China

Yueli Zhu  1 , Zhongju Tan  1 , Shumin Li  1 , Feng Zhu  1 , Chengfan Qin  1 , Qin Zhang  1   2 , Yunmei Yang  1   2
Affiliations

Serum creatinine to cystatin C ratio and cognitive function among middle-aged and older adults in China

Yueli Zhu et al. Front Aging Neurosci. .

Abstract

Background: The sarcopenia index (SI, serum creatinine/serum cystatin C × 100) is recently suggested to be a reliable marker for sarcopenia. It has been reported that sarcopenia is associated with poorer cognition. The purpose of this study was to evaluate the correlation between SI and cognitive function among middle-aged and older adults from the China Health and Retirement Longitudinal Study (CHARLS).

Materials and methods: A total of 6,442 participants ≥45 years of age were enrolled in this study from CHARLS between 2011 and 2012. Cognitive function was assessed by interview-based measurements, including orientation and attention, episodic memory, visuo-construction, and the total cognitive function. SI was calculated by serum creatinine (mg/dL)/cystatin C (mg/L) × 100. One-way analysis of variance (ANOVA) was used to compare the differences among groups divided according to SI quartiles by gender. Both linear and logistic regression models were applied to investigate the relationship between SI and cognitive function.

Results: After adjustment for potential confounders, we found SI was significantly and positively correlated with total cognitive function scores both in males and females [β = 0.014, 95% confidence interval (CI) 0.007 to 0.021, P < 0.001; β = 0.011, 95 CI% 0.003 to 0.018, P = 0.004; respectively]. Similarly, when the total cognitive function score was treated as a categorical variable according to quartiles in males and females, higher SI was related to better total cognitive function scores in both males and females [odds ratio (OR) = 1.147, 95% CI 1.028 to 1.279, P = 0.014; OR = 1.219, 95% CI 1.106 to 1.344, P < 0.001; respectively] following adjustment for confounders.

Conclusions: Lower sarcopenia index was correlated with a higher prevalence of cognitive impairment among middle-aged and older adults in China.

Keywords: cognitive function; creatinine; cystatin C; elders; sarcopenia.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

FIGURE 1
FIGURE 1
Average cognition scores between groups divided by SI quartiles. (A) In the males, (B) in the females. ***The cognition scores among the four groups were significantly different (P < 0.001).
See this image and copyright information in PMC

References

    1. Alzheimer’s Association (2020). 2020 Alzheimer’s disease facts and figures. Alzheimers Dement. [Epub ahead of print]. 10.1002/alz.12068 - DOI - PubMed
    1. Barreto E. F., Poyant J. O., Coville H. H., Dierkhising R. A., Kennedy C. C., Gajic O., et al. (2019). Validation of the sarcopenia index to assess muscle mass in the critically ill: A novel application of kidney function markers. Clin. Nutr. 38 1362–1367. 10.1016/j.clnu.2018.05.031 - DOI - PubMed
    1. Beaudart C., Locquet M., Touvier M., Reginster J. Y., Bruyère O. (2019). Association between dietary nutrient intake and sarcopenia in the SarcoPhAge study. Aging Clin. Exp. Res. 31 815–824. 10.1007/s40520-019-01186-7 - DOI - PubMed
    1. Cabett Cipolli G., Sanches Yassuda M., Aprahamian I. (2019). Sarcopenia is associated with cognitive impairment in older adults: a systematic review and meta-analysis. J. Nutr. Health Aging. 23 525–531. 10.1007/s12603-019-1188-8 - DOI - PubMed
    1. Cruz-Jentoft A. J., Baeyens J. P., Bauer J. M., Boirie Y., Cederholm T., Landi F., et al. (2010). Sarcopenia: European consensus on definition and diagnosis: Report of the European working group on sarcopenia in older people. Age Ageing 39 412–423. 10.1093/ageing/afq034 - DOI - PMC - PubMed

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