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Review
. 2022 Sep 8:12:987491.
doi: 10.3389/fonc.2022.987491. eCollection 2022.

Tumor imaging and photothermal therapy in second near infrared window: A systematic review and meta-analysis

Fuhan Fan  1 , Ya Hou  1 , Yating Zhang  1 , Yong Zeng  1 , Yi Zhang  2 , Sanyin Zhang  3 , Xianli Meng  1   2   3 , Xiaobo Wang  1
Affiliations
Review

Tumor imaging and photothermal therapy in second near infrared window: A systematic review and meta-analysis

Fuhan Fan et al. Front Oncol. .

Abstract

Background: Second near-infrared window (NIR-II, 1000-1700 nm) technology for tumor imaging and photothermal therapy (PTT) is an innovative method for tumor diagnosis and treatment. The NIR-II probe can specifically identify tumor cells, and effectively convert light energy into heat energy under the irradiation of NIR laser, thus achieving the integration of non-invasive tumor diagnosis and treatment. In the present study, we conducted a systematic review and meta-analysis of preclinical investigations to corroborate the efficacy and safety of photothermal therapy.

Methods: Relevant preclinical data were retrieved by searching PubMed, Web of Science, CNKI, WANFANG and VIP information databases. And the acquired data were analyzed by RevMan Version 5.3 software.

Results: According to the inclusion criteria, forty-two articles relating to NIR-II tumor imaging and PTT were recruited for further in-depth analysis. The NIR-II photoacoustic and fluorescence imaging could quickly and accurately identify tumor in mice, manifesting higher signal intensity on tumor site than that of normal tissue. After PTT, the tumor volume of mice decreased miraculously [RR=8.49, 95%CI (4.64, 15.55), P<0.00001], and even disappeared completely [RR=7.01, 95%CI (3.04, 16.13), P<0.00001] with no potential risk of affecting the blood routine.

Conclusions: PTT guided by NIR-II imaging can effectively diagnose the tumor lesion and eliminate it with the advantages of non-invasive and higher biosafety.

Keywords: NIR-II; meta-analysis; photothermal therapy; safety evaluation; tumor imaging.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Schematic diagram of tumor imaging and PTT in the second near-infrared window.
Figure 2
Figure 2
Flow chart of study selection.
Figure 3
Figure 3
Forest plot for PTT effect: (A) Tumor disappeared completely; (B) Tumor shrank but did not completely disappear.
Figure 4
Figure 4
Forrest plots for blood routine: (A) WBC; (B) RBC; (C) MCV; (D) MCH; (E) MCHC.
Figure 5
Figure 5
Imaging capability of NIR-II probe on blood vessels and tumors, and effect of photothermal therapy. (A) Probe IR-820 imaging of cerebral blood vessels in mice at different tissue depths (scale bar: 100 μm) (50); (B) High resolution imaging of tumor vessels at magnification and gaussian fitting curve of vessel cross section (scale bar: 2 mm) (29); (C–E) NIR-II fluorescence imaging and fluorescence intensity of mouse tumors at different time points (31); (D–F) NIR-II photoacoustic imaging and photoacoustic intensity of mouse tumors at different time points (26); (G) Tumor temperature changes at different time points under NIR laser irradiation (18); (H) Tumor photos and volume changes after photothermal treatment under different conditions, from top to bottom: 1) saline; 2) saline + laser; 3) TSSI NPs; 4) TSSI NPs + laser (18).
See this image and copyright information in PMC

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