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. 2022 Aug 15;13(8):643-653.
doi: 10.4239/wjd.v13.i8.643.

Association of rs1137101 with hypertension and type 2 diabetes mellitus of Mongolian and Han Chinese

Ke-Yu Zhao  1 , Meng-Lu Yuan  2 , Yun-Na Wu  3 , Hong-Wei Cui  4 , Wen-Yan Han  5 , Jing Wang  6 , Xiu-Lan Su  7
Affiliations

Association of rs1137101 with hypertension and type 2 diabetes mellitus of Mongolian and Han Chinese

Ke-Yu Zhao et al. World J Diabetes. .

Abstract

Background: Hypertension (HTN) and type 2 diabetes mellitus (T2DM) are often coincident, and each condition is considered a risk factor for the other. Both occur frequently in the Inner Mongolia region of China. The reasons for differences in risk between Han and Mongolian ethnic groups are not known. The LEPR gene and its polymorphism, rs1137101 (Gln223Arg), are both considered risk factors for HTN and T2DM, but any role of rs1137101 in the occurrence of HTN + T2DM remains unclear for Mongolian and Han populations in the Inner Mongolia region.

Aim: To investigate the relationship between rs1137101 and the occurrence of HTN with T2DM in Mongolian and Han populations in Inner Mongolia.

Methods: A total of 2652 subjects of Han and Mongolian ethnic origins were enrolled in the current study, including 908 healthy controls, 1061 HTN patients and 683 HTN patients with T2DM.

Results: The association between the rs1137101 polymorphism and HTN with T2DM was analyzed, and differences between Han and Mongolian individuals assessed. There was a significant correlation between rs1137101 and HTN (co-dominant, dominant, over-dominant and log-additive models) and HTN + T2DM (co-dominant, dominant, over-dominant and log-additive models) after adjustment for sex and age in individuals of Mongolian origin. rs1137101 was significantly associated with HTN (co-dominant, recessive and log-additive models) and HTN + T2DM (co-dominant, dominant, over-dominant and log-additive models) in the Han Chinese population.

Conclusion: Mongolian and Han subjects from Inner Mongolia with HTN who had rs1137101 were protected against the development of T2DM. Allele A has the opposite impact on the occurrence of HTN in Mongolian and Han Chinese populations.

Keywords: Associate study; Han Chinese; Hypertension; Mongolian; Type 2 diabetes mellitus; rs1137101.

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Conflict of interest statement

Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.

Figures

Figure 1
Figure 1
Leptin receptor domains and 3D structure. A: The PFAM database obtains the domains of the leptin receptor (LEPR) protein; B: Swiss-model was used to construct the 3D model of the leptin receptor and the leptin receptor (Q223R) protein fragment 126 to 533. The red frame represented the differences between two models.
See this image and copyright information in PMC

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