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. 2022 Sep 9:10:989337.
doi: 10.3389/fpubh.2022.989337. eCollection 2022.

Seroprevalence of SARS-CoV-2 infection in the Tyrolean district of Schwaz at the time of the rapid mass vaccination in March 2021 following B.1.351-variant outbreak

Peter Willeit  1   2 , Janine Kimpel  3 , Hannes Winner  4 , Teresa Harthaller  3 , Helena Schäfer  3 , David Bante  3 , Barbara Falkensammer  3 , Annika Rössler  3 , Lydia Riepler  3 , Cornelia Ower  5 , Magdalena Sacher  6 , Dorothee von Laer  3 , Wegene Borena  3
Affiliations

Seroprevalence of SARS-CoV-2 infection in the Tyrolean district of Schwaz at the time of the rapid mass vaccination in March 2021 following B.1.351-variant outbreak

Peter Willeit et al. Front Public Health. .

Abstract

In order to curb the rapid dissemination of the B.1.351 variant of SARS-CoV-2 in the district of Schwaz and beyond, the EU allocated additional vaccine doses at the beginning of March 2021 to implement a rapid mass vaccination of the population (16+). The aim of our study was to determine the seroprevalence of SARS-CoV-2 among the adult population in the district of Schwaz at the time of the implementation. Data on previous history of infections, symptoms and immunization status were collected using a structured questionnaire. Blood samples were used to determine SARS-CoV-2 specific anti-spike, anti-nucleocapsid and neutralizing antibodies. We recruited 2,474 individuals with a median age (IQR) of 42 (31-54) years. Using the official data on distribution of age and sex, we found a standardized prevalence of undocumented infections at 15.0% (95% CI: 13.2-16.7). Taken together with the officially documented infections, we estimated that 24.0% (95% CI: 22.5-25.6) of the adult population had prior SARS-CoV-2 infection. Hence, the proportion of undocumented infections identified by our study was 55.8% (95% CI: 52.7-58.5). With a vaccination coverage of 10% among the adults population at that time, we imply that a minimum of two-thirds of the target popuation was susceptible to the circulating threat when this unique campaign started.

Keywords: Comirnaty; SARS-CoV-2; anti-N; beta; seropositivity; seroprevalence; undocumented infection; vaccination.

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Conflict of interest statement

DB declares to hold stocks of Pfizer. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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Supplementary concepts