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. 2022 Sep 7:9:980749.
doi: 10.3389/fnut.2022.980749. eCollection 2022.

Vitamin D supplementation positively affects anthropometric indices: Evidence obtained from an umbrella meta-analysis

Vali Musazadeh  1   2 , Meysam Zarezadeh  1   3 , Faezeh Ghalichi  1   3 , Fateme Hamedi Kalajahi  1   3 , Zohreh Ghoreishi  3
Affiliations

Vitamin D supplementation positively affects anthropometric indices: Evidence obtained from an umbrella meta-analysis

Vali Musazadeh et al. Front Nutr. .

Abstract

Despite the growing evidence from meta-analyses on vitamin D's anti-obesity properties, their results are controversial. The current umbrella review was performed to assess the available evidence and provide a conclusive explanation in this regard. The international databases PubMed, Scopus, Embase, Web of Science and Google Scholar were systematically searched till March, 2022. A random-effects model was used to run the meta-analysis. All meta-analyses that examined the effect of vitamin D supplementation on BW, BMI, WC, and fat mass were included. Findings of 14 meta-analyses revealed that vitamin D supplementation reduced body mass index (BMI) (ES: -0.11 kg/m2; 95% CI: -0.18, -0.05, p?0.001; I 2 = 61.0%, p < 0.001), and waist circumference (WC) (ES = -0.79 cm; 95% CI: -1.20, -0.37; p < 0.001; I 2 = 46.5%, p = 0.096) in comparison to control group. However, the effects of vitamin D on body weight (ES = -0.16 kg, 95% CI: -0.36, 0.04; p = 0.125; I 2 = 57.0%, p = 0.017), and fat mass (ES: 0.02, 95% CI: -0.20, 0.24, p = 0.868; I 2 = 0.0%, p = 0.531) were not considerable. Vitamin D supplementation significantly improved levels of obesity indices such as BMI, and WC.

Keywords: anthropometric indices; body mass index; obesity; umbrella meta-analysis; vitamin D.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

FIGURE 1
FIGURE 1
Flowchart of the study selection.
FIGURE 2
FIGURE 2
The effects of vitamin D supplementation on body weight are depicted in a forest plot with mean differences and 95 percent confidence intervals (CIs).
FIGURE 3
FIGURE 3
Forest plot (A) funnel plot with a mean difference and 95% confidence intervals (CIs) (B) publication bias in the studies reporting, the effects of vitamin D supplementation on BMI levels.
FIGURE 4
FIGURE 4
The effects of vitamin D supplementation on WC (A), and fat mass (B) are depicted in a forest plot with mean differences and 95 percent confidence intervals (CIs).
FIGURE 5
FIGURE 5
The mechanism of action of vitamin D in obesity.
See this image and copyright information in PMC

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