The application of biomaterials in osteogenesis: A bibliometric and visualized analysis

Abstract

Osteogenesis serves an important role in bone tissue repairing. Novel biomaterials are widely prevalent as materials for orthopedic implants due to their biocompatibility and osteogenetic ability. The purpose of this study was to comprehensively analyze hotspots and future trend of biomaterials research in osteogenesis based on bibliometric and visualized analysis. A total of 1,523 papers about biomaterials research in osteogenesis between 2000 and 2021 were included in this study. During the above 20 years, China's leading position in the global biomaterials research in osteogenesis was obvious, and it was also the country that most frequently participates in international cooperation. Chinese Academy of Sciences was the most productive institution and the leader of research cooperation. Acta Biomaterialia and Biomaterials have published the largest number of articles in the field of biomaterials research in osteogenesis. Meanwhile, Acta Biomaterialia and Biomaterials were also the two journals with the highest total citation frequency. Wu CT, Chang J, Kaplan DL, and Xiao Y all made important contributions in the field of biomaterials research in osteogenesis. At present, there are five research hotspots in the field of biomaterials research in osteogenesis: 1) the immunomodulatory role of biomaterial-related inflammatory; 2) mechanisms of osteogenesis in biomaterials; 3) 3D printing and clinical application of biomaterials; 4) bone tissue engineering for biomaterial osteogenesis; and 5) regenerative medicine for biomaterial osteogenesis. The results of this study showed that mechanisms of osteogenesis in biomaterials, bone tissue engineering for biomaterial osteogenesis, and regenerative medicine for biomaterial osteogenesis will remain research hotspots in the future. International cooperation was also expected to expand and deepen the field of biomaterials research in osteogenesis.

Keywords: bibliometric analysis; biomaterials; orthopedic implants; osseointegration; osteogenesis.

FIGURE 1

Flowchart of data screening and excluding.

FIGURE 2

Annual number of the published publication in biomaterials research in osteogenesis from 2000 to 2021.

FIGURE 3

The distribution of countries or regions in biomaterials research in osteogenesis. (A) Distribution of biomaterials research in osteogenesis literatures in the world map. The color of each country or region on the world map represents the amount of literature published, according to the color gradient in the lower left corner. (B) The network map of cooperation between countries or regions. Different colors represent different countries or regions, the area of each color represents the amount of literature published in each country or region, and the thickness of the connecting line indicates the cooperation frequency.

FIGURE 4

Co-authorship overlay visualization map of institutions. The color of each circle corresponds to the average publication year, the size of a circle is proportional to the number of literatures, and the thickness of the connecting line indicates the cooperation frequency.

FIGURE 5

The distribution of authors in biomaterials research in osteogenesis. (A) Author co-authorship overlay visualization map. The color of each circle corresponds to the average publication year of the author, the size of a circle is proportional to the number of literatures published by the author, and the thickness of the connecting line indicates the cooperation frequency. (B) Author co-citation overlay visualization map. The color of each circle corresponds to the average publication year of the author, the size of a circle is proportional to the total number of citations of the author, and the thickness of the connecting line indicates the strength of the co-citation link.

FIGURE 6

Research hotspots in the field of biomaterials research in osteogenesis. (A) Visualized matrix of biclustering of highly frequent keywords in the field of biomaterials research in osteogenesis. Color of each blot represented the frequency of occurrence of keywords in all literatures. (B) Mountain visualization of biclustering of highly frequent keywords in the field of biomaterials research in osteogenesis. The height and color of the mountain are proportional to internal similarity and standard deviation of cluster. Blue: high deviation, Red: low deviation.

FIGURE 7

Co-occurrence overlay visualization map of keywords. The color of each circle corresponds to the average publication year. The size of a circle is proportional to the frequency of occurrence of the keyword, and the thickness of the connecting line indicates the strength of the keywords co-occurrence link.