Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2022 Aug 2;24(4):611.
doi: 10.3892/etm.2022.11548. eCollection 2022 Oct.

Influence of type II diabetes mellitus on postoperative complications following colorectal cancer surgery

Răzvan Cătălin Popescu  1   2 , Nicoleta Leopa  1   2 , Eugen Dumitru  2   3 , Anca Florentina Mitroi  4 , Cristina Tocia  2   3 , Andrei Dumitru  2   3 , Costel Brînzan  4 , Florin Botea  5
Affiliations

Influence of type II diabetes mellitus on postoperative complications following colorectal cancer surgery

Răzvan Cătălin Popescu et al. Exp Ther Med. .

Abstract

Diabetes mellitus (DM) promotes colorectal cancer (CRC) carcinogenesis through complex processes and is considered as an independent risk factor for cancer in general and for CRC in particular. Diabetic patients have complications in the postoperative period following CRC surgery. The aim of the present study was to explore the effect of type II DM (T2DM) on postoperative outcomes for CRC compared with non-diabetic patients. The present study analyzed the data from patients admitted to the General Surgery Department, Emergency Hospital of Constanța (Romania) diagnosed with CRC and DM compared with a control group (patients with CRC, without DM, recruited in the same period and frequency matched to cases by number, sex and age) analyzing patient comorbidities and postoperative complications. A total of 61 patients had undergone surgery for CRC and met the inclusion criteria in the present study conducted during September 2020-2021. A total of 30 patients associated T2DM. Diabetic patients have been associated with more comorbidities than non-diabetics; the age-adjusted Charlson comorbidity index score ≥6 was identified in 90% of diabetic patients compared with 45.2% of controls. Grade III Clavien-Dindo classification was observed in 13.3% diabetic patients compared with 3.2% of non-diabetic patients. Additionally, a higher rate of urinary and pulmonary complications (6.7 vs. 3.2% in controls respectively) in patients with diabetes was found. Postoperative hospitalization was prolonged in diabetic patients (P=0.042). Univariate and multivariate analyses revealed that the laparoscopic approach for diabetic patients was found to be associated with <grade III Clavien-Dindo classification (P=0.040) and the absence of surgical site infection (P=0.040). Diabetes predisposes patients to numerous postoperative complications following CRC surgery and postoperative therapeutic conduct must be personalized to prevent possible postoperative complications following CRC.

Keywords: colorectal cancer; diabetes mellitus; laparoscopy; postoperative complications; surgery.

PubMed Disclaimer

Conflict of interest statement

The authors declare that they have no competing interests.

References

    1. International Agency for Research on Cancer (IARC): Colorectal Cancer. IARC Press, Lyon, 2020. https://gco.iarc.fr/today/data/factsheets/cancers/10_8_9-Colorectum-fact.... Accessed March 1, 2022.
    1. Cho NH, Shaw JE, Karuranga S, Huang Y, da Rocha Fernandes JD, Ohlrogge AW, Malanda B. IDF Diabetes atlas: Global estimates of diabetes prevalence for 2017 and projections for 2045. Diabetes Res Clin Pract. 2018;138:271–281. doi: 10.1016/j.diabres.2018.02.023. - DOI - PubMed
    1. Lin X, Xu Y, Pan X, Xu J, Ding Y, Sun X, Song X, Ren Y, Shan PF. Global, regional, and national burden and trend of diabetes in 195 countries and territories: An analysis from 1990 to 2025. Sci Rep. 2020;10(14790) doi: 10.1038/s41598-020-71908-9. - DOI - PMC - PubMed
    1. Patterson CC, Harjutsalo V, Rosenbauer J, Neu A, Cinek O, Skrivarhaug T, Rami-Merhar B, Soltesz G, Svensson J, Parslow RC, et al. Trends and cyclical variation in the incidence of childhood type 1 diabetes in 26 European centres in the 25 year period 1989-2013: A multicentre prospective registration study. Diabetologia. 2019;62:408–417. doi: 10.1007/s00125-018-4763-3. - DOI - PubMed
    1. Leopa N, Dumitru E, Dumitru A, Tocia C, Prazaru MD, Costea DO, Popescu RC. The clinicopathological differences of colon cancer in young adults versus older adults. J Adolesc Young Adult Oncol, Mar 18, 2022 (Epub ahead of print). - PubMed