Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Observational Study
. 2023 Jan;43(1):109-117.
doi: 10.1007/s00296-022-05208-y. Epub 2022 Sep 26.

Screening for spondyloarthritis in patients with inflammatory bowel diseases

Sébastien Ottaviani #  1 , Xavier Tréton #  2 , Marine Forien  3 , Romain Coralli  3 , Astrid Dauchez  3 , Carmen Stefanescu  2 , Anne-Laure Pelletier  4 , Hakim Becheur  4 , Esther Ebstein  3 , Yoram Bouhnik #  2 , Philippe Dieudé #  3
Affiliations
Observational Study

Screening for spondyloarthritis in patients with inflammatory bowel diseases

Sébastien Ottaviani et al. Rheumatol Int. 2023 Jan.

Abstract

Inflammatory bowel diseases (IBDs) can be associated with various musculoskeletal (IBD-MSK) manifestations that could be difficult to classify for gastroenterologists. We aimed to evaluate the characteristics of patients with IBD-MSK and the prevalence of spondyloarthritis (SpA). In this observational cross-sectional study, we included patients with IBD-MSK complaints (peripheral or back pain). All patients underwent a standardized rheumatology evaluation including clinical, biological and imaging evaluations (MRI of spine and sacroiliac joints and ultrasonography of enthesis). We included 183 IBD patients (60.7% women; median [interquartile range] age 45 [36-56] years); 159 (87%) had joint pain. In 43 (23.5%) and 25/175 (14.3%) patients, enthesis abnormalities were found on ultrasonography and sacroiliitis on MRI, respectively. SpA was diagnosed in 54 (29.5%) patients. IBD-related arthralgia and degenerative spine disease were diagnosed in 105 (57.4%) and 72 (39.3%) patients. Sixteen (29.6%) SpA patients initiated a new conventional synthetic disease modifying anti-rheumatic drug (DMARD). A biologic DMARD was initiated in 10 patients or changed in 3. More than half of IBD-MSK patients had IBD-related arthralgia, and about one-third had definite SpA. Ultrasonography of enthesis and systematic MRI of sacroiliac joints seem useful for SpA classification and differential diagnosis in these patients who often have musculoskeletal pain complaints. Therapeutics were changed in most patients, which highlights the need for a multidisciplinary approach for managing IBD with extra-intestinal symptoms.

Keywords: Inflammatory bowel disease; Musculoskeletal disorders; Spondyloarthritis.

PubMed Disclaimer

References

    1. Abraham C, Cho JH (2009) Inflammatory bowel disease. N Engl J Med 361(21):2066–2078. https://doi.org/10.1056/NEJMra0804647 - DOI
    1. Bouhnik Y (2006) Extradigestive manifestations of chronic intestinal inflammatory diseases. Rev Med Interne 27(Suppl 2):S51-53. https://doi.org/10.1016/j.revmed.2006.03.017 - DOI
    1. van Erp SJ, Brakenhoff LK, van Gaalen FA, van den Berg R, Fidder HH, Verspaget HW, Huizinga TW, Veenendaal RA, Wolterbeek R, van der Heijde D, van der Meulen-de Jong AE, Hommes DW (2016) Classifying back pain and peripheral joint complaints in inflammatory bowel disease patients: a prospective longitudinal follow-up study. J Crohns Colitis 10(2):166–175. https://doi.org/10.1093/ecco-jcc/jjv195 - DOI
    1. Orchard TR, Wordsworth BP, Jewell DP (1998) Peripheral arthropathies in inflammatory bowel disease: their articular distribution and natural history. Gut 42(3):387–391 - DOI
    1. Karreman MC, Luime JJ, Hazes JMW, Weel A (2017) The prevalence and incidence of axial and peripheral spondyloarthritis in inflammatory bowel disease: a systematic review and meta-analysis. J Crohns Colitis 11(5):631–642. https://doi.org/10.1093/ecco-jcc/jjw199 - DOI

Publication types

Substances

LinkOut - more resources