Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2023:2572:181-189.
doi: 10.1007/978-1-0716-2703-7_14.

Alternative In Vivo Models to Study Teratoma

Michela Corsini  1 , Stefania Mitola  2
Affiliations

Alternative In Vivo Models to Study Teratoma

Michela Corsini et al. Methods Mol Biol. 2023.

Abstract

Embryonic stem cells give rise to teratomas when injected in vivo in experimental animal models. The characterization, the manipulation, and the breaking off of this specific characteristic are doubtlessly the last frontier for the applications of stem cells in translational medicine. Moreover, the urgency to adapt to new scientific demands drives the researcher to find alternative and faster models for testing the teratogenic properties of embryonic stem cells. Here, we compare the emerging model of the chick embryo chorioallantoic membrane (CAM) to the murine model, which represents the gold standard procedure for teratogenesis.

Keywords: Chick embryo CAM; ESC differentiation; Embryonic stem cells; Teratoma.

PubMed Disclaimer

References

    1. Peterson CM, Buckley C, Holley S, et al. (2012) Teratomas: a multimodality review. Curr Probl Diagn Radiol 41: 210–2019. Available from: https://doi.org/10.1067/j.cpradiol.2012.02.001
    1. Vitorovic D, Rosenblum J, Thomas C et al (2012) Primary CNS teratocarcinoma. Front Neurol 3:14 - DOI
    1. Hammen I, Lal Yadav A (2018) Teratoma as unusual cause of chest pain, hemoptysis and dyspnea in a young patient. Respir Med Case Rep 23:77–79. Available from: https://doi.org/10.1016/j.rmcr.2017.12.006
    1. Aleckovic M, Simón C (2008) Is teratoma formation in stem cell research a characterization tool or a window to developmental biology? Reprod Biomed Online 17:270–280. Available from: https://doi.org/10.1016/S1472-6483(10)60206-4
    1. Blum B, Benvenisty N (2007) Clonal analysis of human embryonic stem cell differentiation into Teratomas. Stem Cells 25:1924–1930 - DOI

Publication types

LinkOut - more resources