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Meta-Analysis
. 2023 Oct;29(7):2734-2746.
doi: 10.1111/odi.14385. Epub 2022 Oct 11.

Salivary biomarkers to evaluate psychological disorders in oral lichen planus: A systematic review with meta-analysis

Alessandra Laís Pinho Valente Pires  1 , Lísia Daltro Borges Alves  1 , Adriana Mendonça da Silva  1 , Franco Arsati  2 , Ynara Bosco de Oliveira Lima-Arsati  2 , Jean Nunes Dos Santos  3 , Rodrigo Tripody Calumby  4 , Valéria Souza Freitas  1
Affiliations
Meta-Analysis

Salivary biomarkers to evaluate psychological disorders in oral lichen planus: A systematic review with meta-analysis

Alessandra Laís Pinho Valente Pires et al. Oral Dis. 2023 Oct.

Abstract

Objective: To analyze the use of salivary biomarkers to identify psychological disorders (anxiety, depression, and stress) in individuals with oral lichen planus (OLP).

Materials and methods: The search was made in Medline/Pubmed, Scopus, Web of Science, Virtual Health Library, ProQuest, and by cross-reference. Original case-control, cross-sectional, and cohort studies, in human subjects (age ≥18 years) with clinical and histopathological diagnosis, with or without the use of psychometric scales, published until June 2021, were included. Random-effects meta-analyses, subgroup analyses, and sensitivity were performed. Publication bias was measured using the Egger test and visual inspection of the funnel plot.

Results: A total of 67 articles were found, of which 12 were included in the meta-analysis. Among the different biomarkers identified, it was only possible to perform a meta-analysis for cortisol. The mean difference between salivary cortisol levels in patients with OLP compared to controls was 3.43 ng/ml (95% CI: 1.20-5.65) with I2 = 98.9%. Studies considered outliers were removed and based on sensitivity analyses, results did not change, therefore, being stable.

Conclusion: The studies analyzed demonstrated that cortisol was the most quantified biomarker to identify psychological disorders; however, DHEA, IgA, adiponectin, and α-amylase were also evaluated.

Keywords: anxiety; biomarkers; depression; oral lichen planus; stress.

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