Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2023 May 1;45(4):220-222.
doi: 10.1097/MPH.0000000000002548. Epub 2022 Sep 19.

Stage M Infantile Neuroblastoma With Involvement of Falx Cerebri: Case Report and Literature Review

Affiliations
Review

Stage M Infantile Neuroblastoma With Involvement of Falx Cerebri: Case Report and Literature Review

Miyu Sai et al. J Pediatr Hematol Oncol. .

Abstract

Neuroblastoma is the most common extracranial solid tumor in children. When metastasis to the falx cerebri is present, it is classified as stage M; however, its behavior has not been well characterized. Here we present a case of stage M infantile neuroblastoma (NB) with involvement of the falx cerebri, and also summarize the clinical profiles of previously reported cases. Notably, all of the tumors resolved with low-dose chemotherapy alone. Although further study is needed to distinguish NBs presenting at these different intracranial locations, NB with metastasis to the falx cerebri may be categorized as MS when diagnosed at less than 18 months of age.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

References

    1. Maris JM. Recent advances in neuroblastoma. N Engl J Med. 2010;362:2202–2211.
    1. Kramer K, Kushner B, Heller G, et al. Neuroblastoma metastatic to the central nervous system. The Memorial Sloan-Kettering Cancer Center experience and a literature review. Cancer. 2001;91:1510–1519.
    1. Quackenbush KE, Luna-Fineman S, Magee JF, et al. Neuroblastoma involvement of the falx cerebri. Pediatr Blood Cancer. 2009;53:1337–1339.
    1. Kushner BH, Kramer K, Modak S, et al. A focal lesion in the falx cerebri: Harbinger of classic stage 4 neuroblastoma in an infant cured despite residual disease after minimal therapy. Pediatr Blood Cancer. 2009;53:1340–1342.
    1. Bunetti A, Tedeschi E, Belfiore G, et al. Metastasi di neuroblastoma alla falce cerebrale. Presentazione di un caso Radiol Med. 1992;83:467–470.