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Comment
. 2022 Nov;38(11):921-923.
doi: 10.1016/j.pt.2022.09.005. Epub 2022 Sep 23.

Housebreaking Plasmodium parasites leave their fingerprints at the door

Lara Bardtke  1 , Ian A Cockburn  2
Affiliations
Comment

Housebreaking Plasmodium parasites leave their fingerprints at the door

Lara Bardtke et al. Trends Parasitol. 2022 Nov.

Abstract

Protective antibodies against Plasmodium falciparum merozoite antigens, including EBA-175, can inhibit erythrocyte invasion. New data from Musasia et al. indicate that these antibodies can also trigger antibody-dependent phagocytosis of ring-infected and uninfected erythrocytes and that this correlates with protection from malaria. This provides a new pathway for vaccine design.

Keywords: EBA-175; Plasmodium; blood stages; cytophilic antibodies; malaria; phagocytosis.

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Conflict of interest statement

Declaration of interests The authors declare no competing interests.

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