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. 2022 Sep 26;19(1):153.
doi: 10.1186/s12985-022-01881-4.

Traces of JC polyomavirus in papillary thyroid cancer: a comprehensive study in Iran

Amir Ali Karimi  1 , Rahil Tarharoudi  2 , Zahra Kianmehr  3 , Fatemeh Sakhaee  4 , Fatemeh Rahimi Jamnani  4   5 , Seyed Davar Siadat  4   5 , Abolfazl Fateh  6   7
Affiliations

Traces of JC polyomavirus in papillary thyroid cancer: a comprehensive study in Iran

Amir Ali Karimi et al. Virol J. .

Abstract

Background: JC polyomavirus (JCPyV) is known to induce solid tumors such as astrocytomas, glioblastomas, and neuroblastomas in experimental animals, and recent studies have shown that the virus may be correlated with carcinogenesis. This study aimed to evaluate the impact of JCPyV on the progression of papillary thyroid cancer (PTC).

Methods: A total of 1057 samples, including 645 paraffin-embedded PTC biopsy samples (PEBS) and 412 fresh biopsy samples (FBS), and 1057 adjacent non-cancerous samples were evaluated for the presence of JCPyV DNA and RNA.

Results: We observed that 10.8% (114/1057) samples, including 17.5% (72/412) FBS and 6.5% (42/645) PEBS were positive for the JCPyV DNA. Among the JCPyV-positive samples, the mean JCPyV copy number was lower in patients with PEBS (0.3 × 10-4 ± 0.1 × 10-4 copies/cell) compared to FBS (1.8 × 10-1 ± 0.4 × 10-1 copies/cell) and non-PTC normal samples (0.2 × 10-5 ± 0.01 × 10-5 copies/cell), with a statistically significant difference (P < 0.001). The LT-Ag RNA expression was lower in PEBS than in FBS, while no VP1 gene transcript expression was found.

Conclusions: Although our results confirmed the presence of JCPyV in some Iranian patients with PTC, more research is needed to verify these results.

Keywords: JCPyV; Non-cancerous sample; Papillary thyroid cancer.

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Conflict of interest statement

The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

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