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Meta-Analysis
. 2022 Sep 17:2022:1960244.
doi: 10.1155/2022/1960244. eCollection 2022.

Diagnostic Performance of Transient Elastography Versus Two-Dimensional Shear Wave Elastography for Liver Fibrosis in Chronic Viral Hepatitis: Direct Comparison and a Meta-Analysis

Qing-Tian Luo  1   2 , Qing Zhu  3 , Xiao-Dan Zong  4 , Ming-Kai Li  5 , Hong-Sheng Yu  5 , Chang-Yu Jiang  1 , Xiang Liao  1
Affiliations
Meta-Analysis

Diagnostic Performance of Transient Elastography Versus Two-Dimensional Shear Wave Elastography for Liver Fibrosis in Chronic Viral Hepatitis: Direct Comparison and a Meta-Analysis

Qing-Tian Luo et al. Biomed Res Int. .

Abstract

Objective: This systematic review and meta-analysis aimed to compare the diagnostic performance of transient elastography (TE) and two-dimensional shear wave elastography (2D-SWE) for staging liver fibrosis in patients with chronic viral hepatitis (CVH).

Methods: Pubmed, Embase, Web of Science, and Cochrane Library were searched (-01/08/2021) for studies comparing TE with 2D-SWE in patients with CVH. Other etiologies of chronic liver disease (CLD) and articles not published in SCI journals were excluded. The bivariate random-effects model was used to pool the performance of the TE and 2D-SWE.

Results: Eight articles with a total of 1301 CVH patients were included. The prevalence of significant fibrosis (fibrosis stage ≥ 2), advanced fibrosis (fibrosis stage ≥ 3), and cirrhosis was 50.8%, 44.8%, and 34.7%, respectively. 2D-SWE expressed higher overall accuracy than TE in detecting significant fibrosis (0.93 vs. 0.85, P = 0.04). No significant difference among the overall diagnostic accuracy of TE and 2D-SWE in staging advanced fibrosis and cirrhosis was found.

Conclusion: TE and 2D-SWE express good to excellent diagnostic accuracies to stage fibrosis in CVH patients. 2D-SWE compares favorably with TE especially for predicting significant fibrosis.

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Conflict of interest statement

The authors of this manuscript declare no relationships with any companies, whose products or services may be related to the subject matter of the article.

Figures

Figure 1
Figure 1
Flow diagram of the study selection. 150 × 160 mm (300 × 300 DPI).
Figure 2
Figure 2
Summary of methodological quality of 8 studies according to Quality Assessment of Diagnostic Studies-2 (QUADAS-2) tool. (a) Overall and (b) study-level of bias. 150 × 160 mm (300 × 300 DPI).
Figure 3
Figure 3
The SROC curves of TE and 2D-SWE showing performance in staging fibrosis stage F ≥ 2. (a) SROC plot of TE for fibrosis stage F ≥ 2. (b) SROC plot of 2D-SWE for fibrosis stage F ≥ 2. 2D-SWE: two-dimensional shear wave elastography; SROC: summary receiver operating characteristic; TE: transient elastography. 150 × 75 mm (300 × 300 DPI).
Figure 4
Figure 4
The SROC curves of TE and 2D-SWE showing performance in staging fibrosis stage F ≥ 3. (a) SROC plot of TE for fibrosis stage F ≥ 3. (b) SROC plot of 2D-SWE for fibrosis stage F ≥ 3. 2D-SWE: two-dimensional shear wave elastography; SROC: summary receiver operating characteristic; TE: transient elastography. 150 × 75 mm (300 × 300 DPI).
Figure 5
Figure 5
The SROC curves of TE and 2D-SWE showing performance in staging cirrhosis. (a) SROC plot of TE for fibrosis stage F = 4. (b) SROC plot of 2D-SWE for fibrosis stage F = 4. 2D-SWE: two-dimensional shear wave elastography; SROC: summary receiver operating characteristic; TE: transient elastography. 150 × 75 mm (300 × 300 DPI).
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