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Meta-Analysis
. 2022 Sep 27:11:e79002.
doi: 10.7554/eLife.79002.

The effect of calcium supplementation in people under 35 years old: A systematic review and meta-analysis of randomized controlled trials

Yupeng Liu #  1 , Siyu Le #  2 , Yi Liu  2 , Huinan Jiang  2 , Binye Ruan  2 , Yufeng Huang  2 , Xuemei Ao  2 , Xudong Shi  2 , Xiaoyi Fu  2 , Shuran Wang  2
Affiliations
Meta-Analysis

The effect of calcium supplementation in people under 35 years old: A systematic review and meta-analysis of randomized controlled trials

Yupeng Liu et al. Elife. .

Abstract

Background: The effect of calcium supplementation on bone mineral accretion in people under 35 years old is inconclusive. To comprehensively summarize the evidence for the effect of calcium supplementation on bone mineral accretion in young populations (≤35 years).

Methods: This is a systematic review and meta-analysis. The Pubmed, Embase, ProQuest, CENTRAL, WHO Global Index Medicus, Clinical Trials.gov, WHO ICTRP, China National Knowledge Infrastructure (CNKI), and Wanfang Data databases were systematically searched from database inception to April 25, 2021. Randomized clinical trials assessing the effects of calcium supplementation on bone mineral density (BMD) or bone mineral content (BMC) in people under 35 years old.

Results: This systematic review and meta-analysis identified 43 studies involving 7,382 subjects. Moderate certainty of evidence showed that calcium supplementation was associated with the accretion of BMD and BMC, especially on femoral neck (standardized mean difference [SMD] 0.627, 95% confidence interval [CI] 0.338-0.915; SMD 0.364, 95% CI 0.134-0.595; respectively) and total body (SMD 0.330, 95% CI 0.163-0.496; SMD 0.149, 95% CI 0.006-0.291), also with a slight improvement effect on lumbar spine BMC (SMD 0.163, 95% CI 0.008-0.317), no effects on total hip BMD and BMC and lumbar spine BMD were observed. Very interestingly, subgroup analyses suggested that the improvement of bone at femoral neck was more pronounced in the peripeak bone mass (PBM) population (20-35 years) than the pre-PBM population (<20 years).

Conclusions: Our findings provided novel insights and evidence in calcium supplementation, which showed that calcium supplementation significantly improves bone mass, implying that preventive calcium supplementation before or around achieving PBM may be a shift in the window of intervention for osteoporosis.

Funding: This work was supported by Wenzhou Medical University grant [89219029].

Keywords: calcium; calcium supplementation; epidemiology; global health; none; osteoporosis; peak bone mass.

Plain language summary

Osteoporosis and bone fractures are common problems among older people, particularly older women. These conditions cause disability and reduce quality of life. Progressive loss of bone mineral density is usually the culprit. So far, strategies to prevent bone weakening with age have produced disappointing results. For example, taking calcium supplements in later life only slightly reduces the risk of osteoporosis or fracture. New approaches are needed. Bone mass increases gradually early in life and peaks and plateaus around 20-35 years of age. After that period, bone mass slowly declines. Some scientists suspect that increasing calcium intake during this period of peak bone mass may reduce osteoporosis or fracture risk later in life. A meta-analysis by Liu, Le et al. shows that boosting calcium intake in young adulthood strengthens bones. The researchers analyzed data from 43 randomized controlled trials that enrolled 7,382 participants. About half the studies looked at the effects of taking calcium supplements and the other half analyzed the effects of a high calcium diet. Boosting calcium intake in people younger than age 35 improved bone mineral density throughout the body. It also increased bone mineral density at the femoral neck, where most hip fractures occur. Calcium supplementation produced larger effects in individuals between the ages of 20 and 35 than in people younger than 20. Both high calcium diets and calcium supplements with doses less than 1000 mg/d boosted bone strength. Higher dose calcium supplements did not provide any extra benefits. The analysis suggests people should pay more attention to bone health during early adulthood. Large randomized clinical trials are needed to confirm the long-term benefits of boosting calcium intake during early adulthood. But if the results are validated, taking calcium supplements, or eating more calcium-rich foods between the ages of 20 and 35 may help individuals build healthier bones and prevent fractures and osteoporosis later in life.

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Conflict of interest statement

YL, SL, YL, HJ, BR, YH, XA, XS, XF, SW No competing interests declared

Figures

Figure 1.
Figure 1.. Study selection.
Figure 2.
Figure 2.. Effect of calcium supplmentation on bone mineral density (BMD) in each site.
Figure 3.
Figure 3.. Effect of calcium supplmentation on bone mineral content (BMC) in each site.
Figure 4.
Figure 4.. Comparison of the effect of calcium supplementation between prepeak and peripeak participants.
See this image and copyright information in PMC

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