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Review
. 2022 Nov 1;33(6):543-550.
doi: 10.1097/ICU.0000000000000895. Epub 2022 Sep 19.

Peripheral ulcerative keratitis due to systemic diseases

Affiliations
Review

Peripheral ulcerative keratitis due to systemic diseases

Amol A Sura et al. Curr Opin Ophthalmol. .

Abstract

Purpose of review: To discuss peripheral ulcerative keratitis, with a focus on the evaluation and management of associated systemic diseases.

Recent findings: Peripheral ulcerative keratitis (PUK) is a sight-threatening condition that is often defined by the presence of a crescent-shaped area of peripheral corneal thinning, an epithelial defect, and an inflammatory corneal infiltrate. It is highly associated with rheumatoid arthritis, systemic necrotizing vasculitides like granulomatosis with polyangiitis, and collagen vascular diseases like systemic lupus erythematosus. Undertreated PUK carries a risk of vision loss and premature death.

Summary: Multidisciplinary collaboration between the ophthalmologist, rheumatologist, and other consultants is required. Early and aggressive steroid-sparing therapy should be considered in cases due to noninfectious systemic disease.

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References

    1. El Bahloul M, Lambarki O, Bennis A, et al. Severe chronic peripheral ulcerative keratitis: approach to diagnosis and treatment. J Fr Ophtalmol 2021; 44:e231–e233.
    1. Gupta Y, Kishore A, Kumari P, et al. Peripheral ulcerative keratitis. Surv Ophthalmol 2021; 66:977–998.
    1. Cao Y, Zhang W, Wu J, et al. Peripheral ulcerative keratitis associated with autoimmune disease: pathogenesis and treatment. J Ophthalmol 2017; 2017:7298026.
    1. Galor A, Thorne JE. Scleritis and peripheral ulcerative keratitis. Rheum Dis Clin North Am 2007; 33:835–854. vii.
    1. Keenan JD, Mandel MR, Margolis TP. Peripheral ulcerative keratitis associated with vasculitis manifesting asymmetrically as fuchs superficial marginal keratitis and terrien marginal degeneration. Cornea 2011; 30:825–827.