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Multicenter Study
. 2023 Jan;26(1):43-50.
doi: 10.1111/1756-185X.14442. Epub 2022 Sep 27.

The impact of nail psoriasis on disease activity, quality of life, and clinical variables in patients with psoriatic arthritis: A cross-sectional multicenter study

Gizem Cengiz  1 , Kemal Nas  2 , Yaşar Keskin  3 , Erkan Kılıç  4 , Betül Sargin  5 , Sevtap Acer Kasman  6 , Hakan Alkan  7 , Nilay Sahin  8 , Nihan Cüzdan Balta  9 , İlknur Albayrak Gezer  10 , Dilek Keskin  11 , Cevriye Mülkoğlu  12 , Hatice Reşorlu  13 , Şebnem Ataman  14 , Ajda Bal  15 , Merve Baykul  2 , Mehmet Tuncay Duruöz  6 , Okan Küçükakkaş  3 , Ozan Volkan Yurdakul  3 , Meltem Alkan Melikoğlu  16 , Fikriye Figen Ayhan  17 , Hatice Bodur  18 , Mustafa Çaliş  1 , Erhan Çapkin  19 , Gül Devrimsel  20 , Kevser Gök  21 , Sami Hizmetli  22 , Ayhan Kamanlı  2 , Hilal Ecesoy  23 , Öznur Kutluk  24 , Nesrin Şen  25 , Ömer Faruk Şendur  5 , İbrahim Tekeoğlu  2 , Murat Toprak  26 , Sena Tolu  27 , Tiraje Tuncer  24
Affiliations
Multicenter Study

The impact of nail psoriasis on disease activity, quality of life, and clinical variables in patients with psoriatic arthritis: A cross-sectional multicenter study

Gizem Cengiz et al. Int J Rheum Dis. 2023 Jan.

Abstract

Aim: Nail involvement is common in psoriatic arthritis. This study assesses clinical characteristics, nail psoriasis prevalence, and impact of nail psoriasis on disease activity in patients with psoriatic arthritis (PsA).

Method: This cross-sectional multicenter study was conducted by the Turkish League Against Rheumatism using PsA patients recruited from 25 centers. Demographic and clinical characteristics of PsA patients, such as disease activity measures, quality of life, and nail involvement findings were assessed during routine follow-up examinations. Patients were divided into two groups according to the presence or absence of nail psoriasis and compared using the χ2 test or Fisher exact test for categorical variables and the t-test or Mann-Whitney U test for continuous variables.

Results: In 1122 individuals with PsA, 645 (57.5%) displayed nail psoriasis. The most frequent features of fingernails were ridges (38%), followed by pitting (21%) and onycholysis (19%). More females were present in both groups (with and without nail psoriasis; 64% vs 67%, P < 0.282). Patients with nail psoriasis were older, indicated more pain and fatigue, experienced greater swelling, tender joint counts, and skin disease severity, and had a higher disease activity score compared with those without nail psoriasis (all P < 0.05).

Conclusion: We demonstrate an increased prevalence of nail psoriasis observed in patients with psoriatic arthritis. Patients with nail involvement experience increased disease activity, lower quality of life, and diminished mental and physical status compared with those without nail involvement.

Keywords: clinical characteristics; disease activity; nail involvement; nail psoriasis; psoriatic arthritis; quality of life.

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References

REFERENCES

    1. Veale DJ, Fearon U. The pathogenesis of psoriatic arthritis. Lancet. 2018;391(10136):2273-2284.
    1. Ocampo DV, Gladman D. Psoriatic arthritis. F1000Res. 2019;8:1-16.
    1. Gladman D, Antoni C, Mease P, Clegg D, Nash P. Psoriatic arthritis: epidemiology, clinical features, course, and outcome. Ann Rheum Dis. 2005;64(suppl 2):ii14-ii17.
    1. Kurd SK, Gelfand JM. The prevalence of previously diagnosed and undiagnosed psoriasis in US adults: results from NHANES 2003-2004. J Am Acad Dermatol. 2009;60(2):218-224.
    1. Griffiths CE, Barker JN. Pathogenesis and clinical features of psoriasis. Lancet. 2007;370(9583):263-271.

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