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Multicenter Study
. 2023 Jan;35(2):206-215.
doi: 10.1111/den.14446. Epub 2022 Nov 9.

Endoscopic resection for gastric submucosal tumors: Japanese multicenter retrospective study

Satoki Shichijo  1 , Nobutsugu Abe  2 , Hirohisa Takeuchi  2 , Ken Ohata  3 , Yohei Minato  3 , Kazutoshi Hashiguchi  4 , Kingo Hirasawa  5 , Shoichi Kayaba  6 , Hirohiko Shinkai  6 , Hideki Kobara  7 , Takeshi Yamashina  8 , Tsukasa Ishida  9 , Hideyuki Chiba  10 , Hiroyuki Ono  11 , Hirohito Mori  12 , Noriya Uedo  1
Affiliations
Multicenter Study

Endoscopic resection for gastric submucosal tumors: Japanese multicenter retrospective study

Satoki Shichijo et al. Dig Endosc. 2023 Jan.

Abstract

Objectives: Limited information is available on the efficacy and safety of endoscopic resection (ER) of gastric submucosal tumors (SMTs) in Japanese endoscopic practice where ER for gastric tumors is extremely popular.

Methods: We conducted this study to elucidate the current scenario of ER for gastric SMTs in Japanese endoscopic practice. Patients (from 12 institutions) with gastric SMTs who underwent ER were enrolled from the first case until August 2020.

Results: We enrolled 117 patients with 118 lesions. The number of patients who underwent ER increased over the years. The mean endoscopic tumor size was 20 ± 7.2 (8-40) mm. The growth type was primarily intraluminal (90%). The mean resection and wound closure times were 58 ± 38 (range, 12-254) min and 31 ± 41 (range, 3-330) min, respectively. Complete ER was achieved for 117 (99%) lesions. Full-thickness resection rate was 44%; however, only 12 (10%) patients required abdominal paracentesis for decompression. Endoscopic treatments were completed in 115 (97%) lesions, while three lesions required conversions to laparoscopic surgery due to luminal collapse, uncontrolled bleeding, and difficulty in defect closure. Gastrointestinal stromal tumors were the most common pathology (74%). No recurrence was observed during the mean follow-up period of 4.3 ± 2.9 years. The 5-year overall survival rate was 98.9% (95% confidence interval 97.8-100%).

Conclusion: Performance of ER for gastric SMTs is increasing in Japan. The technique seems feasible in Japanese endoscopic practice, warranting further validation in a prospective study.

Keywords: complete resection; endoscopic full thickness resection; submucosal tumor.

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References

REFERENCES

    1. Hedenbro JL, Ekelund M, Wetterberg P. Endoscopic diagnosis of submucosal gastric lesions. The results after routine endoscopy. Surg Endosc 1991; 5: 20-3.
    1. Lim YJ, Son HJ, Lee JS et al. Clinical course of subepithelial lesions detected on upper gastrointestinal endoscopy. World J Gastroenterol 2010; 16: 439-44.
    1. Japan Society of Clinical Oncology. Clinical practice guideline for gastrointestinal stromal tumor [Internet], Tokyo: Japan Society of Clinical Oncology; 2014 [cited 2022 Nov 7]. Available from: http://jsco-cpg.jp/item/03/index.html. Japanese.
    1. Demetri GD, Benjamin RS, Blanke CD et al. NCCN Task Force report: Management of patients with gastrointestinal stromal tumor (GIST)-Update of the NCCN clinical practice guidelines. J Natl Compr Canc Netw 2007; 5 (Suppl 2): S1-29.
    1. Casali PG, Abecassis N, Aro HT et al. Gastrointestinal stromal tumours: ESMO-EURACAN clinical practice guidelines for diagnosis, treatment and follow-up. Ann Oncol 2018; 29 (Suppl 4): iv68-78.

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