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. 2021 Jun 24;1(1):e4.
doi: 10.1017/ash.2021.164. eCollection 2021.

Impact of BioFire FilmArray respiratory panel results on antibiotic days of therapy in different clinical settings

Jenna J Manatrey-Lancaster  1 , Amanda M Bushman  1 , Meagan E Caligiuri  1 , Rossana Rosa  2   3
Affiliations

Impact of BioFire FilmArray respiratory panel results on antibiotic days of therapy in different clinical settings

Jenna J Manatrey-Lancaster et al. Antimicrob Steward Healthc Epidemiol. .

Abstract

Objective: The BioFire FilmArray Respiratory Panel (RFA) has been proposed as a tool that can aid in the timely diagnosis and treatment of respiratory tract infections but its effect on antibiotic prescribing among adult patients has varied. We evaluated the impact of RFA result on antibiotic days of therapy (DOTs) in 2 distinct cohorts: hospitalized patients and patients discharged from the emergency department (ED).

Design: Retrospective cohort study.

Setting: The study was conducted in 3 community hospitals in Des Moines, Iowa, from March 3 to March 16, 2019.

Patients: Adults aged >18 years.

Methods: Potential outcome means and average treatment effects for RFA results on antibiotic DOTs were estimated. Inverse probability of treatment weighting with regression adjustment was used.

Results: We identified 243 patients each in the hospitalized and ED-discharged cohorts. Among hospitalized patients, RFA results did not affect antibiotic DOTs. Among patients discharged from the ED, we found that if all patients had had influenza detected, the average DOTs would have been 2.3 DOTs (-3.2 to -1.4) less than the average observed if all the patients had had a negative RFA (P < .0001); no differences in DOTs were observed when comparing an RFA with a noninfluenza virus detected compared to an RFA with negative results.

Conclusions: The impact of RFA results on antibiotic DOTs varies by clinical setting, and reductions were observed only among patients discharged from the ED who had influenza A or B detected.

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Conflict of interest statement

All authors report no conflicts of interest relevant to this article.

References

    1. Brittain-Long R, Westin J, Olofsson S, Lindh M, Andersson LM. Access to a polymerase chain reaction assay method targeting 13 respiratory viruses can reduce antibiotics: a randomised, controlled trial. BMC Med 2011;9:44. - PMC - PubMed
    1. Lozano R, Naghavi M, Foreman K, et al. Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet 2012;380:2095–2128. - PMC - PubMed
    1. Fendrick AM, Monto AS, Nightengale B, Sarnes M. The economic burden of non–influenza-related viral respiratory tract infection in the United States. Arch Intern Med 2003;163:487–494. - PubMed
    1. Green DA, Hitoaliaj L, Kotansky B, Campbell SM, Peaper DR. Clinical utility of on-demand multiplex respiratory pathogen testing among adult outpatients. J Clin Microbiol 2016;54:2950–2955. - PMC - PubMed
    1. Stolz D, Christ-Crain M, Gencay MM, et al. Diagnostic value of signs, symptoms and laboratory values in lower respiratory tract infection. Swiss Med Wkly 2006;136:434–440. - PubMed

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