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. 2022 Sep 12;9(9):ofac464.
doi: 10.1093/ofid/ofac464. eCollection 2022 Sep.

Risk of Long COVID in People Infected With Severe Acute Respiratory Syndrome Coronavirus 2 After 2 Doses of a Coronavirus Disease 2019 Vaccine: Community-Based, Matched Cohort Study

Daniel Ayoubkhani  1   2 , Matthew L Bosworth  1 , Sasha King  3 , Koen B Pouwels  4   5 , Myer Glickman  1 , Vahé Nafilyan  1   6 , Francesco Zaccardi  2 , Kamlesh Khunti  2 , Nisreen A Alwan  7   8   9 , A Sarah Walker  4   10
Affiliations

Risk of Long COVID in People Infected With Severe Acute Respiratory Syndrome Coronavirus 2 After 2 Doses of a Coronavirus Disease 2019 Vaccine: Community-Based, Matched Cohort Study

Daniel Ayoubkhani et al. Open Forum Infect Dis. .

Abstract

We investigated long COVID incidence by vaccination status in a random sample of UK adults from April 2020 to November 2021. Persistent symptoms were reported by 9.5% of 3090 breakthrough severe acute respiratory syndrome coronavirus 2 infections and 14.6% of unvaccinated controls (adjusted odds ratio, 0.59 [95% confidence interval, .50-.69]), emphasizing the need for public health initiatives to increase population-level vaccine uptake.

Keywords: COVID-19; coronavirus; long COVID; post-COVID condition; vaccination.

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Conflict of interest statement

Potential conflicts of interest. K. K. chairs the long COVID research-funded group reporting to the Chief Medical Officer, chairs the Ethnicity Subgroup of the UK Scientific Advisory Group for Emergencies (SAGE), and is a member of SAGE. All other authors report no potential conflicts.

Figures

Figure 1.
Figure 1.
Adjusted odds ratios for long COVID symptoms ≥12 weeks after first infection, comparing matched study participants who were double-vaccinated or unvaccinated (reference group) before infection. Odds ratios adjusted for sociodemographic characteristics (age, sex, White or non-White ethnicity, country/region of residence, area deprivation quintile group, and self-reported, preexisting health/disability status) and time from infection to follow-up for long COVID. Confidence intervals are at the 95% level.
See this image and copyright information in PMC

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