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Editorial
. 2023 Mar 1;207(5):503-504.
doi: 10.1164/rccm.202209-1797ED.

Obesity and COVID-19 Disease: To Inflame or Not

Rebecca F Hough  1 , Peter A Wark  2   3
Affiliations
Editorial

Obesity and COVID-19 Disease: To Inflame or Not

Rebecca F Hough et al. Am J Respir Crit Care Med. .
No abstract available

PubMed Disclaimer

Figures

Figure 1.
Figure 1.
Putative mechanism of obesity-related decrease in the inflammatory response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). (Left) In nonobese patients exposed to SARS-CoV-2, leptin rises, binding leptin receptors (LEPRs) on immune cells. This stimulates Janus kinase-signal transducer and activator of transcription (JAK-STAT) signaling and increases the expression of proinflammatory/antiviral cytokines. (Right) In obese patients, there is leptin resistance at baseline. On SARS-CoV-2 exposure, increased leptin fails to stimulate the LEPR, so there is less stimulation of the JAK-STAT pathway and lower expression of proinflammatory/antiviral cytokines. Created with BioRender.com.
See this image and copyright information in PMC

Comment on

  • Obesity Is Associated with Attenuated Tissue Immunity in COVID-19.
    Guo SA, Bowyer GS, Ferdinand JR, Maes M, Tuong ZK, Gillman E, Liao M, Lindeboom RGH, Yoshida M, Worlock K, Gopee H, Stephenson E, Gao CA, Lyons PA, Smith KGC, Haniffa M, Meyer KB, Nikolić MZ, Zhang Z, Wunderink RG, Misharin AV, Dougan G, Navapurkar V, Teichmann SA, Conway Morris A, Clatworthy MR. Guo SA, et al. Am J Respir Crit Care Med. 2023 Mar 1;207(5):566-576. doi: 10.1164/rccm.202204-0751OC. Am J Respir Crit Care Med. 2023. PMID: 36095143 Free PMC article.

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